Author: Lee SY, Yoon KA, Jang SH, Ganbold EO, Uuriintuya D, Shin SM, Ryu PD, Joo SW.
Affiliation: Laboratory of Pharmacology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
Conference/Journal: J Vet Sci
Date published: 2009 Dec
Other:
Volume ID: 10 , Issue ID: 4 , Pages: 299-304 , Word Count: 106
The vibrational spectral differences of normal and lung cancer cells were studied for the development of effective cancer cell screening by means of attenuated total reflection infrared spectroscopy. The phosphate monoester symmetric stretching nu(s)(PO(3)(2-)) band intensity at ~970 cm(-1) and the phosphodiester symmetric stretching nu(s)(PO(2)(-)) band intensity at ~1,085 cm(-1) in nucleic acids and phospholipids appeared to be significantly strengthened in lung cancer cells with respect to the other vibrational bands compared to normal cells. This finding suggests that more extensive phosphorylation occur in cancer cells. These results demonstrate that lung cancer cells may be prescreened using infrared spectroscopy tools.