Author: Shaoqing Xie1, Yuan Yuan2, Junyu Wang3,4, Ying Bai2, Tao Wang5, Bopeng Qiu6, Yong Yang7, Shu-Cheng Lin8
Affiliation: <sup>1</sup> School of Physical Education and Sport, West Anhui University, Shanghai, 237012, China.
<sup>2</sup> Department of Physical Education, Kunsan National University, Kunsan, 541150, South Korea.
<sup>3</sup> School of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, China.
<sup>4</sup> Officers College of PAP, Chengdu, 610200, China.
<sup>5</sup> School of Physical Education and Institute of Sports Biology, Shaanxi Normal University, Xian, 710119, Shaanxi, China.
<sup>6</sup> School of Strength and Conditioning Training, Beijing Sport University, Beijing, 100084, China.
<sup>7</sup> Laboratory of Kinesiology and Rehabilitation, School of Physical Education and Sport, Chaohu University, No. 1 Xuefu Road, Chaohu Economic Development Zone, Hefei, 238000, Anhui, China. yangyong@henu.edu.cn.
<sup>8</sup> School of Gerontology and Long-Term Care, Taipei Medical University, Taipei City 110, Taiwan (R.O.C.), Taipei, Taiwan. s0975835@gmail.com.
Conference/Journal: Sci Rep
Date published: 2025 Jan 17
Other:
Volume ID: 15 , Issue ID: 1 , Pages: 2239 , Special Notes: doi: 10.1038/s41598-025-85456-7. , Word Count: 235
To examine the dose-response relationship between specific types of exercise for improving walking velocity in Parkinson's disease (PD). This systematic review and network meta-analysis included searches of PubMed, Medline, Embase, PsycINFO, Cochrane Library, and Web of Science were searched from inception until February 18th, 2024. Data analysis was performed using R software with the MBNMA and RJAGS packages. Outcome indicators were measured as mean standard deviation (SMD) along with 95% confidence intervals (95% CrI). The network's risk of bias was independently evaluated by two reviewers employing the ROB2 tool. Our review encompassed 54 studies with 2,828 PD patients, examining the dose-response effects of different exercises on walking velocity. Aerobic Exercise (AE) demonstrated the greatest improvement at an optimal dose of 1,400 METs-min/week (SMD:1.215, 95% Crl: 0.113 to 2.306). Both Multicomponent Exercise (Mul) (SMD: 1.202, 95% Crl: 0.193 to 2.231) and Sensory Exercise (SE) (SMD: 0.649, 95% Crl: 0.139 to 1.183) showed optimal outcomes at a dose of 1,000 METs-min/week. Resistance Training (RT) was most effective at 750 METs-min/week (SMD:0.778, 95% Crl: 0.062 to 1.549), while Mind-Body Exercise (MBE) yielded significant improvements at a lower optimal dose of 500 METs-min/week (SMD: 0.580, 95% Crl: 0.218 to 1.137), offering valuable insights for exercise prescription in PD management. Various types of exercise showed specific optimal benefits at corresponding doses, among which AE was the most effective in improving the walking speed of PD patients at 1,400 Mets*min/week.Trial registration: PROSPERO (CRD42024506919).
Keywords: Bayesian network meta-analysis; Dose–response; Exercise; Parkinson’s disease; RCTs; Walking velocity.
PMID: 39824889 DOI: 10.1038/s41598-025-85456-7