Author: Cynthia J Price1, Kenneth C Pike2, Anna Treadway1, Julia K Palmer1, Joseph O Merrill3
Affiliation: <sup>1</sup> Department of Biobehavioral Nursing and Health Informatics, University of Washington, Box 357266, Seattle, WA 98195, USA.
<sup>2</sup> Department of Family and Community Health Nursing, University of Washington, Box 357262, Seattle, WA 98195, USA.
<sup>3</sup> Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, 325 Ninth Avenue - Box 359780, Seattle, WA 98104, USA.
Conference/Journal: Mindfulness (N Y)
Date published: 2024 Nov 1
Other:
Volume ID: 15 , Issue ID: 11 , Pages: 2794-2811 , Special Notes: doi: 10.1007/s12671-024-02463-x. , Word Count: 318
The need for improve medication for opioid use disorder (MOUD) treatment outcomes can be limited by co-occurring polysubstance use, mental health, and chronic pain conditions. Interoceptive training may facilitate well-being and support medication treatment for MOUD.
Objectives:
While effective, medication for opioid use disorder (MOUD) treatment outcomes can be limited by co-occurring polysubstance use, mental health, and chronic pain conditions. Interoceptive training may facilitate well-being and support medication treatment for MOUD. This study examined the pre-post effects of the mindfulness-based intervention Mindful Awareness in Body-oriented Therapy (MABT) as an adjunct to MOUD. MABT teaches interoceptive awareness skills to promote self-care and emotion regulation.
Method:
Participants stabilized on medication for opioid use disorder (OUD) (n = 303) from six community clinics in North-western United States were recruited and randomly assigned to MABT plus MOUD or MOUD only. In a mixed-methods study, we used an intent-to-treat approach (analyzing participants based on their assigned group, regardless of adherence) to examine the proportion of days abstinent from non-prescribed opioids, and other substance use (primary outcomes) at baseline and 3 months post-intervention. Secondary outcomes included symptoms of mental health distress, emotional regulation difficulties, pain and physical symptom indicators, interoceptive awareness, and mindfulness skills. Participant experience of MABT was collected through post-intervention surveys. Changes in outcomes were assessed using linear mixed models; content analysis was used to analyze the qualitative data.
Results:
Levels of overall substance use were low and did not differ between groups. Significant improvements in PTSD symptoms, interoceptive awareness, pain severity, pain activity interference, and physical symptom frequency were found for those who received MABT compared to MOUD only.
Conclusions:
In this stable MOUD population, substance use outcomes were not improved; however, MABT demonstrated significant positive changes across multiple health outcomes critical for improving MOUD treatment.
Preregistration:
ClinicalTrials.gov identifer: NCT04082637.
Keywords: Interoception; Intervention; Mindfulness; Mixed methods; Opioid use disorder; Randomized controlled trial; Substance use disorder.
PMID: 39697819 PMCID: PMC11654914 DOI: 10.1007/s12671-024-02463-x