Author: Jing Wang1, Xinmin Li2, Fangjie Yang1, Pengxue Guo1, Chunlin Ren1, Zhengfei Duan1, Yasu Zhang3
Affiliation: <sup>1</sup> Rehabilitation Medicine College, Henan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou, Henan, China.
<sup>2</sup> School of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
<sup>3</sup> Rehabilitation Medicine College, Henan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou, Henan, China. zhangyasu16@163.com.
Conference/Journal: J Orthop Surg Res
Date published: 2024 Sep 28
Other:
Volume ID: 19 , Issue ID: 1 , Pages: 586 , Special Notes: doi: 10.1186/s13018-024-05072-5. , Word Count: 325
Objective:
To evaluate the efficacy and safety of mind-body exercise (MBE) interventions, including Tai Chi, Yoga, Pilates, and Qigong, in patients with axial spondyloarthritis (axSpA), a systematic review and meta-analysis was conducted.
Methods:
Eight electronic databases were searched from their inception to May 2024. RevMan 5.4 and Stata 16.0 software were used for statistical analysis. Outcome measures included Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Visual Analog Scale (VAS), Bath Ankylosing Spondylitis Metrology Index (BASMI), Ankylosing Spondylitis Quality of Life (ASQoL) Scale, and adverse events. The methodological quality of the included studies was evaluated using the Cochrane risk of bias (RoB) tool (2.0). The certainty of evidence for each outcome was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria.
Results:
Of the 330 studies retrieved, 15 studies satisfied the criteria for meta-analysis. Compared with the controls, MBE interventions significantly improved physical function (measured by BASFI, MD = -0.76, 95% CI: -1.01 to -0.50, P < 0.00001), disease activity (measured by BASDAI, MD = -0.76, 95% CI: -0.94 to -0.57, P < 0.00001), pain intensity (measured by VAS, MD = -0.89, 95% CI: -1.21 to -0.57, P < 0.00001), spinal mobility (measured by BASMI, MD = -0.44, 95% CI: -0.70 to -0.19, P = 0.0006), and quality of life (measured by ASQoL, MD = -2.14, 95% CI: -3.54 to -0.75, P = 0.003). Subgroup analyses revealed that Tai Chi appeared to demonstrate a more pronounced effect on pain reduction when compared to Qigong (test for subgroup difference: P = 0.005). The quality of evidence for these outcomes was estimated as moderate to low. Additionally, no serious adverse events related to MBE were identified among the included studies.
Conclusions:
Overall, MBE may be a promising non-pharmacological treatment to improve physical function, disease activity, pain intensity, spinal mobility, and quality of life in patients with axSpA. To enhance the certainty of the evidence, additional rigorous studies are needed to verify these findings.
Keywords: Ankylosing spondylitis; Axial spondyloarthritis; Exercise; Mind body therapy; Mind-body exercise; Systematic review.
PMID: 39342350 PMCID: PMC11438100 DOI: 10.1186/s13018-024-05072-5