Heart Rate Variability and Autonomic Nervous System Imbalance: Potential Biomarkers and Detectable Hallmarks of Aging and Inflammaging

Author: Fabiola Olivieri1, Leonardo Biscetti2, Lorenzo Pimpini3, Giuseppe Pelliccioni2, Jacopo Sabbatinelli4, Sergio Giunta5
Affiliation: <sup>1</sup> Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; Advanced Technology Center for Aging Research and Geriatric Mouse Clinic, IRCCS INRCA, Ancona, Italy. <sup>2</sup> Unit of Neurology, IRCCS INRCA, Ancona, Italy. <sup>3</sup> Cardiology Unit, IRCCS INRCA, Ancona, Italy. <sup>4</sup> Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; Clinic of Laboratory and Precision Medicine, IRCCS INRCA, Ancona, Italy. Electronic address: j.sabbatinelli@staff.univpm.it. <sup>5</sup> Casa di Cura Prof. Nobili (Gruppo Garofalo GHC), Castiglione dei Pepoli, Bologna, Italy.
Conference/Journal: Ageing Res Rev
Date published: 2024 Sep 26
Other: Pages: 102521 , Special Notes: doi: 10.1016/j.arr.2024.102521. , Word Count: 207


The most cutting-edge issue in the research on aging is the quest for biomarkers that transcend molecular and cellular domains to encompass organismal-level implications. We recently hypothesized a role of Autonomic Nervous System (ANS) imbalance in this context. Studies on ANS functions during aging highlighted an imbalance towards heightened sympathetic nervous system (SNS) activity, instigating a proinflammatory milieu, and attenuated parasympathetic nervous system (PNS) function, which exerts anti-inflammatory effects via the cholinergic anti-inflammatory pathway (CAP) and suppression of the hypothalamic-pituitary-adrenal (HPA) axis. This scenario strongly suggests that ANS imbalance can fuel inflammaging, now recognized as one of the most relevant risk factors for age-related disease development. Recent recommendations have increasingly highlighted the need for actionable strategies to improve the quality of life for older adults by identifying biomarkers that can be easily measured, even in asymptomatic individuals. We advocate for considering ANS imbalance as a biomarker of aging and inflammaging. Measures of ANS imbalance, such as heart rate variability (HRV), are relatively affordable, non-invasive, and cost-effective, making this hallmark easily diagnosable. HRV gains renewed significance within the aging research landscape, offering a tangible link between pathophysiological perturbations and age-related health outcomes.

Keywords: Autonomic nervous system imbalance; clinical biomarkers; heart rate variability; inflammaging; macrophages.

PMID: 39341508 DOI: 10.1016/j.arr.2024.102521