Author: Fengya Zhu1, Shao Yin2, Tingting Ma2, Liuying Li3, Siyun Li3, Junqian Liu4, Yuan Wang4, Siyi Mao4, Jie Wu5
Affiliation: <sup>1</sup> Zigong First People's Hospital, Zigong, China; Chengdu University of Traditional Chinese Medicine, Chengdu, China.
<sup>2</sup> Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
<sup>3</sup> Zigong First People's Hospital, Zigong, China; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
<sup>4</sup> Chengdu University of Traditional Chinese Medicine, Chengdu, China.
<sup>5</sup> Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. Electronic address: drwujie@163.com.
Conference/Journal: Asian J Psychiatr
Date published: 2023 Dec 21
Other:
Volume ID: 91 , Pages: 103882 , Special Notes: doi: 10.1016/j.ajp.2023.103882. , Word Count: 404
Background:
Acupuncture has been widely used in the treatment of neurodegenerative diseases and a large number of systematic reviews (SRs) have been published, but the results are controversial. Therefore, it is necessary to comprehensively summarize and objectively evaluate the clinical evidence of acupuncture for neurodegenerative diseases.
Objective:
To evaluate the SRs that assess the efficacy and safety of acupuncture for neurodegenerative diseases. This overview is intended to provide evidence for clinical decision making by healthcare providers and policymakers and to provide evidence for clinical decision making by healthcare providers and policymakers and to provide recommendations for researchers to conduct high quality SRs and clinical studies.
Methods:
We searched four Chinese databases (SinoMed, CNKI, Wanfang and VIP) and four international databases (Cochrane Library, Embase, PubMed and Web of Science) for SRs of acupuncture for neurodegenerative diseases. The search period ran from the beginning of the database to March 5, 2023. Literature screening and data extraction were performed independently by two individuals. Methodological quality, risk of bias and associated evidence levels were assessed for all SRs using AMSTER 2, ROBIS and GRADE tools. In addition, the RCT overlap between SRs was calculated by corrected coverage area (CCA). We also conducted quantitative synthesis or descriptive analysis of the relevant data.
Results:
Finally, we identified 53 SRs (three were qualitative descriptions and fifty were meta-analyses). Under AMSTAR 2, only one SR was rated as moderate quality, six SRs as low quality and 46 SRs as very low quality. According to ROBIS, 33 SRs were rated as a high risk of bias and 20 as a low risk of bias. Cognitive functions in neurodegenerative diseases, activities of daily living and the motor and non-motor outcomes associated with PD were included to summary description. The pooled results show that acupuncture combined with conventional treatment may have an overall advantage over conventional treatment, but the quality of evidence is low. Specific adverse reactions/events were reported in 20 SRs. Common needle-related adverse events included pain, dizziness, bleeding, or subcutaneous hematoma. No severe adverse events were reported in any SRs.
Conclusion:
Evidence suggests that acupuncture is generally effective and relatively safe for cognitive function and activities of daily living in neurodegenerative diseases. In addition, acupuncture may have some benefits in improving motor and non-motor symptoms in patients with PD. However, high-quality RCTs and SRs are still needed to further clarify the efficacy and safety of acupuncture in treating neurodegenerative diseases.
Keywords: Acupuncture; Neurodegenerative disease; Overview; Systematic reviews.
PMID: 38150809 DOI: 10.1016/j.ajp.2023.103882