Psychoneuroimmunology of Meditation

Author: Dipti Magan1, Raj Kumar Yadav2
Affiliation: <sup>1</sup> Department of Physiology, All India Institute of Medical Sciences, Bathinda, Punjab, India. <sup>2</sup> Department of Physiology, All India Institute of Medical Sciences, New Delhi, Delhi, India.
Conference/Journal: Ann Neurosci
Date published: 2022 Apr 1
Other: Volume ID: 29 , Issue ID: 2-3 , Pages: 170-176 , Special Notes: doi: 10.1177/09727531221109117. , Word Count: 188

Meditation is a conscious mental discipline, that has been implicated in the relaxation response. The mechanism behind such a relaxing effect is psychoneuroimmunology (PNI), based on the interaction between mind, physical health, and self-healing; that conceptualizes that stress and an individual's emotional state led to predisposition to diseases. Research to date suggests that meditation may play an active role in remodeling the imbalance between mind and body by modulating the psychoneuroimmunological effects of stress. However, to date, the multi-dimensional psychoneuroimmune aspects of meditation together have not been completely explicated. An evidence-based mechanism has been framed for the first time in India to explain the psychoneuroimmunology of regular and long-term meditation practice.

Present evidence-based mechanism confirms prefrontal cortex (PFC) acts as a 'Functional Connectome' where psycho-neuro-immune aspects of meditation function simultaneously to exert positive benefits in the regulation of cognitive and emotional behavior. Also, this mechanism will help us to understand how human augmentation with lifestyle modification fosters brain plasticity to overcome various neuropsychiatric illnesses.

Key message:
Meditation is a scientific tool against neuro-psychiatric illnesses.

Keywords: Diseases; Evidence-based research; Health; Meditation; Psychoneuroimmunology; Stress.

PMID: 36419515 PMCID: PMC9676346 DOI: 10.1177/09727531221109117