Author: Xiaomei Liu1, Zhuoya Ma1, Xinyi Zhu1, Zhiwei Zheng1, Jing Li1, Jiangning Fu1, Qi Shao1, Xiaoyan Han2, Xiaoning Wang2, Zhihui Wang3, Zhaoxue Yin3, Chengxuan Qiu4, Juan Li5
Affiliation: <sup>1</sup> Center on Aging Psychology (XL, ZM, XZ, ZZ, JL, JF, QS, JL), CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology (XL, ZM, XZ, ZZ, JL, JF, QS, JL), University of Chinese Academy of Sciences, Beijing, China. <sup>2</sup> Chaoyang District Center for Disease Control and Prevention (XH, XW), Beijing, China. <sup>3</sup> Chinese Center for Disease Control and Prevention (ZW, ZY), Beijing, China. <sup>4</sup> Aging Research Center (CQ), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden. <sup>5</sup> Center on Aging Psychology (XL, ZM, XZ, ZZ, JL, JF, QS, JL), CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology (XL, ZM, XZ, ZZ, JL, JF, QS, JL), University of Chinese Academy of Sciences, Beijing, China. Electronic address: email@example.com.
Conference/Journal: Am J Geriatr Psychiatry
Date published: 2022 Nov 1
Other: Special Notes: doi: 10.1016/j.jagp.2022.10.006. , Word Count: 229
We sought to assess cognitive benefits of a community-based multidomain intervention for improving cognition among older adults at risk of cognitive decline (COMBAT).
A two-armed cluster-randomized controlled trial.
Setting and participants:
Community-dwelling older adults aged 60 years or older and were at risk of cognitive decline (n = 209).
In this 9-month intervention study, 10 community hospitals in Beijing, China, were randomized (1:1) to receive either a multidomain intervention of meditation, cognitive training, exercise, and nutrition counseling or usual care. The intervention was delivered with weekly 1-hour group training sessions and weekly home homework.
Primary outcome was change in cognition as measured by a composite Z score of seven cognitive tests. Secondary outcomes included subjective cognitive abilities, positive and negative affective experiences, physical activity, and dietary habits. Assessments were administered at baseline, end of the intervention, and 1 year after completing the intervention (1-year follow-up).
Immediately after the intervention, the intervention group showed significant enhancement in cognitive performance (p = 0.026). The between-group difference in the Z score of change of cognition was 0.20 (95% CI: 0.053, 0.35), with a Hedges' g of 0.40 (95% CI: 0.29, 0.50). However, this cognitive benefit was not significant at 1-year follow-up.
This multidomain intervention was effective to improve cognition for at-risk individuals. Long-term effects on cognitive function and individual differences in response to the intervention deserve further investigation.
Keywords: Multidomain intervention; cluster-randomized controlled trial; cognitive decline; community-based; prevention.
PMID: 36414488 DOI: 10.1016/j.jagp.2022.10.006