Effects of radiation exposure on brain health: a state of the art and new challenges

Author: Jayalakshmi Jayan1, Harsha Roshi1, Fathima Farzana Perumbilly Ashraf1, Parvathy G Nair1, Aparna Vijayakumar1, Aathira Sujathan Nair1, Leena K Pappachen2, Mohamed A Abdelgawad3, Della Grace Thomas Parambi3, Lotfi Aleya4, Bijo Mathew5
Affiliation: <sup>1</sup> Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, 682 041, India. <sup>2</sup> Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, 682 041, India. leenabijudaniel@gmail.com. <sup>3</sup> Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, 2014, Al Jouf, Saudi Arabia. <sup>4</sup> Laboratoire Chrono-Environment, Universite de Bourgogne Franche-Comte, CNRS6249, Besancon, France. <sup>5</sup> Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, 682 041, India. bijomathew@aims.amrita.edu.
Conference/Journal: Environ Sci Pollut Res Int
Date published: 2022 Oct 29
Other: Special Notes: doi: 10.1007/s11356-022-23703-4. , Word Count: 206


Good brain health refers to a condition in which a person may fully realize their talents and improve their psychological, emotional, cognitive, and behavioral functioning to cope with life's challenges. Various causes of CNS diseases are now being investigated. Radiation is one of the factors that affects the brain and causes a variety of problems. The emission or transmission of energy in the form of waves or particles via space or a material medium is known as radiation. Particle beams and electromagnetic waves are two types of ionizing radiation that have the potential to ionize atoms in a material (separating them into positively charged ions and negatively charged electrons). Radiation to the CNS can induce delayed puberty, which can lead to hyperprolactinemia, and the hypothalamic-pituitary axis can lead to gonadotropin deficit if the hypothalamic-pituitary axis is involved in the radiation field. Ionizing radiation is the most common kind of radiation. Here, we focus on the different effects of radiation on brain health. In this article, we will look at a variety of CNS diseases and how radiation affects each one, as well as how it affects the brain's numerous processes.

Keywords: Alzheimer’s disease; Multiple sclerosis; Parkinson’s disease; Radiation.

PMID: 36308656 DOI: 10.1007/s11356-022-23703-4