Author: Guang Yang1, Qun Dong2, Huixin Yang3, Fan Wang3, Linwei Chen3, Junze Tang3, Guoyuan Huang4, Ying Zhao1
Affiliation: <sup>1</sup> Physical Education Department, Shanghai Jiao Tong University, Shanghai 200042, China.
<sup>2</sup> Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
<sup>3</sup> Institute of Nation Traditional Sports, Harbin Sport University, Harbin 150006, China.
<sup>4</sup> Pott College of Science, Engineering and Education, University of Southern Indiana, Indiana, IN 47712, USA.
Conference/Journal: Genes (Basel)
Date published: 2022 Oct 15
Other:
Volume ID: 13 , Issue ID: 10 , Pages: 1863 , Special Notes: doi: 10.3390/genes13101863. , Word Count: 221
Parkinson's disease (PD) is a common progressive neurodegenerative disease characterized by motor dysfunction. Although the inhibition of inflammation by Tai Chi has been demonstrated to involve a peripheral cytokine response and may play an important role in improving the motor function of PD patients, the related specific molecular mechanisms of the peripheral immune response to Tai Chi are not fully understood. The microarray dataset 'GSE124676' for the peripheral immune response to Tai Chi of PD patients was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened and analyzed using weighted gene co-expression network analysis (WGCNA). A total of 136 DEGs were found in the PD patients after Tai Chi, suggesting an effect of Tai Chi on the peripheral immunity of PD patients. The DEGs are mainly involved in neutrophil activation, T-cell activation, and NOD-like receptor and IL-17 signaling pathways. Furthermore, six key candidate genes (FOS, FOSB, JUNB, ZFP36, CAMP and LCN2) that are involved in peripheral inflammation and the inhibition of inflammation induced by Tai Chi were observed. The results in the present study could be conducive to comprehensively understanding the molecular mechanism involved in the effect of Tai Chi on peripheral inflammation in PD patients and providing novel targets for future advanced research.
Keywords: DEGs; Parkinson’s disease; Tai Chi; WGCNA; peripheral inflammation.
PMID: 36292747 DOI: 10.3390/genes13101863