Meditation-based intervention for obsessive-compulsive disorder: A PRISMA-compliant systematic review and meta-analysis

Author: Si Myeong Lee1, Hyo-Weon Suh2, Hui-Yong Kwak1, Jong Woo Kim1,3, Sun-Yong Chung1,3
Affiliation: <sup>1</sup> Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul, Republic of Korea. <sup>2</sup> College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul, Republic of Korea. <sup>3</sup> Department of Neuropsychiatry, Kyung Hee University Korean Medicine Hospital at Gangdong, 892 Dongnam-ro, Gangdong-gu, Seoul, Republic of Korea.
Conference/Journal: Medicine (Baltimore)
Date published: 2022 Jul 29
Other: Volume ID: 101 , Issue ID: 30 , Pages: e29147 , Special Notes: doi: 10.1097/MD.0000000000029147. , Word Count: 279

The purpose of this study was to investigate the effects of the meditation-based intervention on obsessive-compulsive disorder (OCD).

The following databases were searched up to April 2021: the Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, Medline (via PubMed), PsycARTICLES, 4 Korean databases (Korean Medical Database [KMbase], Koreanstudies Information Service System [KISS], National Digital Science Library [NDSL], and Oriental Medicine Advanced Searching Integrated System [OASIS]), and China National Knowledge Infrastructure (CNKI). The search terms related to meditation-based intervention and OCD were used. This systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The selected articles were evaluated using the Cochrane risk of bias tool. The Review Manager (RevMan) 5.4 was used to perform the meta-analysis.

In all, 16 randomized controlled trials were selected. The meta-analysis showed that the group receiving the treatment combining medication and meditation-based intervention for OCD showed a more significant post-treatment improvement in Yale-Brown obsessive compulsive scale than the group receiving medication only. Compared with other non-medication interventions that are known to be effective in treating OCD, the Yale-Brown obsessive compulsive scale showed a significant improvement immediately after the meditation-based intervention. However, no significant difference was found in the follow-up monitoring data across all examined cases.

This study was conducted to verify the effects of meditation-based intervention on OCD. The results suggested that combined treatment with medication and meditation-based intervention was more effective in treating OCD than medication alone; the positive effects of meditation-based intervention may be greater than the effects of other non-medication interventions. However, the lack of significant difference in the follow-up indicates that long-term effect of meditation-based interventions is unclear.

Trial registration number:
PROSPERO CRD42021244408.

PMID: 35905202 DOI: 10.1097/MD.0000000000029147