Clinical perspectives on vagus nerve stimulation: present and future

Author: Eibhlin Goggins1, Shuhei Mitani2, Shinji Tanaka2
Affiliation: <sup>1</sup> Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, U.S.A. <sup>2</sup> Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Conference/Journal: Clin Sci (Lond)
Date published: 2022 May 13
Other: Volume ID: 136 , Issue ID: 9 , Pages: 695-709 , Special Notes: doi: 10.1042/CS20210507. , Word Count: 95

The vagus nerve, the great wanderer, is involved in numerous processes throughout the body and vagus nerve stimulation (VNS) has the potential to modulate many of these functions. This wide-reaching capability has generated much interest across a range of disciplines resulting in several clinical trials and studies into the mechanistic basis of VNS. This review discusses current preclinical and clinical evidence supporting the efficacy of VNS in different diseases and highlights recent advancements. Studies that provide insights into the mechanism of VNS are considered.

Keywords: neuro–immune interactions; optogenetics; vagus nerve stimulation.

PMID: 35536161 DOI: 10.1042/CS20210507