The Lonely Brain - Associations Between Social Isolation and (Cerebro-) Vascular Disease From the Perspective of Social Neuroscience

Author: Janine Gronewold1, Miriam Engels2
Affiliation: <sup>1</sup> Department of Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Essen, Germany. <sup>2</sup> Institute of Medical Sociology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Conference/Journal: Front Integr Neurosci
Date published: 2022 Jan 28
Other: Volume ID: 16 , Pages: 729621 , Special Notes: doi: 10.3389/fnint.2022.729621. , Word Count: 221

The current COVID-19 pandemic led to a considerable reduction in in-person social contacts all over the world. In most individuals, reduced social contacts lead to the perception of social isolation causing feelings of loneliness, which are experienced as stressful. Experiencing social distress due to actual or perceived social isolation has been associated with negative health outcomes such as depression, (cerebro-) vascular disease and mortality. Concrete mechanisms behind this association are still a matter of debate. A group of researchers around Hugo Critchley with special contributions of Sarah Garfinkel and Lisa Quadt proposes a framework for the underlying brain-body interactions including elements from models of social homeostasis and interoceptive predictive processing that provides important insights and testable pathways. While in a previous publication, we reviewed literature on the observed association between social isolation and stroke and coronary heart disease, we now extent this review by presenting a comprehensive model to explain underlying pathomechanisms from the perspective of social neuroscience. Further, we discuss how neurodivergent people, e.g. autistic individuals or persons with attention deficit disorders, might differ in these pathomechanisms and why they are especially vulnerable to social isolation. Finally, we discuss clinical implications for the prevention and therapy of (cerebro-) vascular diseases.

Keywords: COVID-19; cardiovascular diseases; interoception; neurological models; physiological adaptation; psychological adaptation; social isolation; stroke.

PMID: 35153690 PMCID: PMC8834536 DOI: 10.3389/fnint.2022.729621