Author: Fan He1, Junfen Lin1, Fudong Li1, Yujia Zhai1, Tao Zhang1, Xue Gu1, Genming Zhao2
Affiliation: <sup>1</sup> Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang. China.
<sup>2</sup> Department of Epidemiology, School of Public Health, Fudan University, Shanghai. China.
Conference/Journal: Curr Alzheimer Res
Date published: 2021 Nov 17
Other:
Special Notes: doi: 10.2174/1567205018666211118100451. , Word Count: 245
Background:
The independent effect of physical work on the risk of cognitive impairment in older Chinese adults living in rural areas remains to be elucidated.
Objective:
We aimed to determine whether physical work and physical exercise can reduce the risk of cognitive impairment.
Methods:
We collected data from 7,000 permanent residents without cognitive impairment (age ≥60 years) over a follow-up period of 2 years. We used the Chinese version of the Mini-Mental State Ex- amination (MMSE) to assess cognitive function. We performed multivariate Cox regression analyses to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (%95 CIs) as measures of the association between physical work/exercise and cognitive impairment while controlling for potential confounders.
Results:
Over a median follow-up period of 1.93 years, 1,224 (17.5%) of 7,000 participants developed cognitive impairment, with a total incidence of 97.69 per 1,000 person-years. After adjustment for potential confounders, participating in physical work (HR: 0.51; 95% CI: 0.43-0.60) or physical exer- cise (HR: 0.53; 95% CI: 0.44-0.65) was associated with a reduced risk of cognitive impairment. Strati- fied analyses suggested additive and multiplicative interactions between physical work and exercise. Agricultural work (HR: 0.46; 95% CI: 0.38-0.55), walking/tai chi (HR: 0.54; 95% CI: 0.44-0.67), and brisk walking/yangko (HR: 0.57; 95% CI: 0.33-0.97) exerted significant protective effects against cognitive impairment.
Conclusion:
Both physical work and exercise can reduce the risk of cognitive impairment in older adults. Reasonable types and appropriate intensities of physical activity are recommended to prevent or delay the progression of cognitive impairment.
Keywords: Physical activity; aging; cognitive impairment; hazard ratio; longitudinal study; older adults.
PMID: 34792012 DOI: 10.2174/1567205018666211118100451