Author: Yang Liu1, Qince Li1,2, Kuanquan Wang3, Runnan He1, Zhongquan Dai4, Hongyu Zhang4, Chengyu Liu5, Qianying Ma6, Yongfeng Yuan1, Chengjia Yang4, Yinghui Li4, Henggui Zhang7,8,9
Affiliation: <sup>1</sup> School of Computer Science and Technology, Harbin Institute of Technology (HIT), Harbin , Heilongjiang, China. <sup>2</sup> Peng Cheng Laboratory, Shenzhen, Guangdong, China. <sup>3</sup> School of Computer Science and Technology, Harbin Institute of Technology (HIT), Harbin , Heilongjiang, China. email@example.com. <sup>4</sup> State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China. <sup>5</sup> The State Key Laboratory of Bioelectronics, School of Instrument Science and Engineering, Southeast University, Nanjing, Jiangsu, China. <sup>6</sup> Department of Psychology, Beihang University, Beijing, China. <sup>7</sup> Peng Cheng Laboratory, Shenzhen, Guangdong, China. firstname.lastname@example.org. <sup>8</sup> School of Physics and Astronomy, The University of Manchester, Manchester, UK. email@example.com. <sup>9</sup> Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China. firstname.lastname@example.org.
Conference/Journal: Med Biol Eng Comput
Date published: 2021 Aug 9
Other: Special Notes: doi: 10.1007/s11517-021-02380-4. , Word Count: 217
Fasting has been demonstrated to improve health and slow aging in human and other species; however, its impact on the human body in the confined environment is still unclear. This work studies the effects of long-term fasting and confined environment on the cardiovascular activities of human via a 10-day fasting experiment with two groups of subjects being in confined (6 subjects) and unconfined (7 subjects) environments respectively and undergoing the same four-stage fasting/feeding process. It is found that the confinement has significant influences on the autonomic regulation to the heart rate during the fasting process by altering the activity of the parasympathetic nervous system, which is manifested by the significant higher pNN50, rMSSD, and Ln-HF of heart rate variability (HRV) (p < 0.05) and slower heart rate (p < 0.01) in the confined group than that in the unconfined group. Furthermore, the long-term fasting induces a series of changes in both groups, including reduced level of serum sodium (p < 0.01), increased the serum calcium (p < 0.05), prolonged QTc intervals (p < 0.05), and reduced systolic blood pressures (p < 0.05). These effects are potentially negative to human health and therefore need to be treated with caution. Study of the effects of fasting and confinement on the cardiovascular activities.
Keywords: Cardiovascular system; Confinement; Fasting; Parasympathetic nervous system.
PMID: 34370188 DOI: 10.1007/s11517-021-02380-4