Author: Piotr Piszczek1, Karolina Wójcik-Piotrowicz2, Krzysztof Gil3, Jolanta Kaszuba-Zwoińska3
Affiliation: <sup>1</sup> Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College, 31-121, Krakow, Czysta street 18, Poland. Electronic address: piotr.piszczek@doctoral.uj.edu.pl.
<sup>2</sup> Department of Biophysics, Jagiellonian University Medical College, Łazarza street 16, 31-530, Cracow, Poland.
<sup>3</sup> Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College, 31-121, Krakow, Czysta street 18, Poland.
Conference/Journal: Environ Res
Date published: 2021 Jun 11
Other:
Special Notes: doi: 10.1016/j.envres.2021.111505. , Word Count: 196
Despite many studies, the question about the positive or negative influence of electromagnetic fields (EMF) on living organisms still remains an unresolved issue. To date, the results are inconsistent and hardly comparable between different laboratories. The observed bio-effects are dependent not only on the applied EMF itself, but on many other factors such as the model system tested or environmental ones. In an organism, the role of the defense system against external stressors is played by the immune system consisting of various cell types. The immune cells are engaged in many physiological processes and responsible for the proper functioning of the whole organism. Any factor with an ability to cause immunomodulatory effects may weaken or enhance the response of the immune system. This review is focused on a wide range electromagnetic fields as a possible external factor which may modulate the innate and/or adaptive immunity. Considering the existing databases, we have compiled the bio-effects evoked by EMF in particular immune cell types involved in different types of immune response, with the common mechanistic models and mostly activated intracellular signaling cascade pathways.
Keywords: Electromagnetic fields (EMF); Immune cells; Immune system; Immunomodulatory acting.
PMID: 34126050 DOI: 10.1016/j.envres.2021.111505