Author: Ahmad Tamimi1, Faleh Tamimi2,3, Malik Juweid4, Abdelkarim A Al-Qudah5, Amira Al Masri5, Said Dahbour6, Yakub Al Bahou6, Abdelatif Shareef4, Iskandar Tamimi7
Affiliation: <sup>1</sup> Neurosurgery Department, Jordan University Hospital, Jordan.
<sup>2</sup> College of Dental Medicine, QU Health, Qatar University, Doha, Qatar.
<sup>3</sup> Faculty of Dentistry, McGill University, Canada.
<sup>4</sup> Nuclear Medicine Department, Jordan University Hospital, Jordan.
<sup>5</sup> Pediatric Neurology Department, Jordan University Hospital, Jordan.
<sup>6</sup> Neurology Department, Jordan University Hospital, Jordan.
<sup>7</sup> Orthopedic surgery Department, Hospital Regional Universitario de Malaga, Spain.
Conference/Journal: J Musculoskelet Neuronal Interact
Date published: 2021 Jun 1
Other:
Volume ID: 21 , Issue ID: 2 , Pages: 255-262 , Word Count: 184
Objectives:
To investigate the effect of vagus nerve stimulation (VNS) on the bone mineral density (BMD) in epileptic patients.
Methods:
A prospective cohort study was conducted on individuals with refractory seizures who underwent VNS surgery between January 2012 and December 2018. BMD was measured preoperatively and between 6 months and one year after surgery.
Results:
Twenty-one patients (mean age (±SD)=23.6±12.3 years) were recruited for the implantation of a VNS device. The mean absolute increase in lumbar BMD in the 21 patients was 0.04±0.04 g/cm2 resulting in an overall percent increase from baseline of 4.7±6.1%. BMD increased by an amount ≥ the least significant change (LSC) for the lumbar spine in 13 patients (61.9%). The lumbar Z score also increased in these patients from -1.22±1.15 to -0.88±1.22, P=0.006). Pre and Post VNA femoral BMD was measured in only 11 patients and, of those 3 showed a significant increase in BMD, 1 a significant decrease and 7 no change.
Conclusion:
The implantation of a VNS was associated with an increase in lumbar BMD. This study could lead to a new application for VNS in the treatment of osteoporosis.
Keywords: Bone Mineral Density; Epilepsy; Osteoporosis; Stimulation; Vagus Nerve.
PMID: 34059570