Measurement of tissue optical properties in the context of tissue optical clearing

Author: Alexey N Bashkatov1,2, Kirill V Berezin1, Konstantin N Dvoretskiy3, Maria L Chernavina1, Elina A Genina1,2, Vadim D Genin1, Vyacheslav I Kochubey1,2, Ekaterina N Lazareva1,2,4, Alexander B Pravdin1, Marina E Shvachkina1, Polina A Timoshina1,2, Daria K Tuchina1,2,5, Dmitry D Yakovlev1, Dmitry A Yakovlev1, Irina Yu Yanina1,2, Olga S Zhernovaya1, Valery V Tuchin1,2,6
Affiliation: <sup>1</sup> Saratov State University, Research-Educational Institute of Optics and Biophotonics, Saratov, Russia. <sup>2</sup> Tomsk State University, Interdisciplinary Laboratory of Biophotonics, Tomsk, Russia. <sup>3</sup> Saratov State Medical University, Subdivision of Medical and Biological Physics, Saratov, Russia. <sup>4</sup> Immanuel Kant Baltic Federal University, Center for Functionalized Magnetic Materials, Kaliningrad, Russia. <sup>5</sup> Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia. <sup>6</sup> Institute of Precision Mechanics and Control of the Russian Academy of Sciences, Saratov, Russia.
Conference/Journal: J Biomed Opt
Date published: 2018 Aug 1
Other: Volume ID: 23 , Issue ID: 9 , Pages: 1-31 , Special Notes: doi: 10.1117/1.JBO.23.9.091416. , Word Count: 142

Nowadays, dynamically developing optical (photonic) technologies play an ever-increasing role in medicine. Their adequate and effective implementation in diagnostics, surgery, and therapy needs reliable data on optical properties of human tissues, including skin. This paper presents an overview of recent results on the measurements and control of tissue optical properties. The issues reported comprise a brief review of optical properties of biological tissues and efficacy of optical clearing (OC) method in application to monitoring of diabetic complications and visualization of blood vessels and microcirculation using a number of optical imaging technologies, including spectroscopic, optical coherence tomography, and polarization- and speckle-based ones. Molecular modeling of immersion OC of skin and specific technique of OC of adipose tissue by its heating and photodynamic treatment are also discussed.

Keywords: biological tissues; fat; in vitro; optical clearing; optical properties; polarization; refractive index; skin.

PMID: 30141286 DOI: 10.1117/1.JBO.23.9.091416