A 12-Week Multi-Modal Exercise Program: Feasibility of Combined Exercise and Simplified 8-Style Tai Chi Following Lung Cancer Surgery

Author: Ting Lu1, Linda Denehy2,3, Yuejiao Cao1, Qirui Cong1, En Wu1, Catherine L Granger2,4, Jun Ni1,5, Lara Edbrooke2,3
Affiliation: <sup>1</sup> Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. <sup>2</sup> The University of Melbourne, Parkville, Victoria, Australia. <sup>3</sup> Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. <sup>4</sup> Royal Melbourne Hospital, Parkville, Victoria, Australia. <sup>5</sup> The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Conference/Journal: Integr Cancer Ther
Date published: 2020 Jan-Dec
Other: Volume ID: 19 , Pages: 1534735420952887 , Special Notes: doi: 10.1177/1534735420952887. , Word Count: 226

To assess the feasibility, safety, and preliminary effect of a 12-week multi-modal rehabilitation program targeted at improving health-related quality of life and physical activity levels of patients with lung cancer following treatment.

Patients with stage I to IIIA non-small cell lung cancer were included 6 to 12 weeks following completion of treatment. The intervention comprised of aerobic exercise (brisk walking), resistance training and 8-style Tai Chi. The 12-week program included 2 supervised center-based sessions per week of 90 minutes duration and home-based exercise. The primary outcomes were the feasibility and safety of the intervention. Secondary outcomes (assessed pre and post program) were physical and patient-reported outcomes.

Seventy-eight patients were approached during the 6-month recruitment period and 17 (22%) consented to the study. Eight participants (47%) met the definition of adherence to the program (attending at least 70% of supervised sessions). No serious adverse events occurred. A significant reduction in anxiety and depression was observed post-program. In addition, improvements in respiratory function, sleep quality, and some health-related quality of life domains were observed post-program. There were no significant differences in functional capacity or physical activity levels.

This multi-modal exercise training program was safe, although the feasibility of the program in its current state is not supported given the low consent rate and low adherence to the intervention.

Keywords: Tai Chi; exercise; health-related quality of life; lung cancer; physical activity.

PMID: 32851871 DOI: 10.1177/1534735420952887