Author: Devesh Oberoi¹, Katherine-Ann L Piedalue^{1 2}, Hassan Pirbhai^{1 2}, Steven Guirguis³, Daniel Santa Mina^{3 4}, Linda E Carlson^{5 6}
Affiliation: 1 Psychosocial Resources, Tom Baker Cancer Centre, Holy Cross Site Phase I, 2202-2 St SW, Calgary, AB, T2S 3C1, Canada. 2 Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Health Sciences Centre Foothills Campus, 3330 Hospital Drive NW, Calgary, T2N 4N1, AB, Canada. 3 Cancer Rehabilitation and Survivorship Program, Princess Margaret Cancer Centre, B PMB 130, 200 Elizabeth St, Toronto, ON, M5G 2C4, Canada. 4 Faculty of Kinesiology and Physical Education, University of Toronto, 55 Harbord Street, Toronto, ON, M5S 2W6, Canada. 5 Psychosocial Resources, Tom Baker Cancer Centre, Holy Cross Site Phase I, 2202-2 St SW, Calgary, AB, T2S 3C1, Canada. lcarlso@ucalgary.ca. 6 Psychosocial Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Health Sciences Centre Foothills Campus, 3330 Hospital Drive NW, Calgary, T2N 4N1, AB, Canada. lcarlso@ucalgary.ca.
Conference/Journal: BMC Res Notes
Date published: 2020 Jul 17
Other: Volume ID: 13 , Issue ID: 1 , Pages: 342 , Special Notes: doi: 10.1186/s13104-020-05172-5. , Word Count: 164

PMID: 32680556 DOI: 10.1186/s13104-020-05172-5

Abstract

Objective: To examine the factors associated with loss to follow-up (LTFU) in an ongoing preference-based randomized waitlist controlled trial of mindfulness-based cancer recovery (MBCR) and Taichi/Qigong (TCQ) for cancer survivors (the MATCH Study). Hierarchical logistic regression was used to determine the factors associated with LTFU. Predictors included adherence to treatment, preference vs. randomized, type of intervention (MBCR vs. TCQ) and program timing (immediate {IM} vs. waitlist control {WLC} group).

Results: Data indicated that randomization to the WLC group and, once in the intervention, low adherence were the main predictors of LTFU. Participants in the WLC group were 4 times more likely to be LTFU post-randomization [OR 3.96, 95% CI 2.08-7.56, p < 0.005] than those in the IM group. Participants showing low adherence to treatment were 6 times more likely for LTFU post-intervention [5.87 (2.57-13.400; p < 0.005] and 4 times more likely for LTFU 6 months post-intervention [OR 3.93, 95% CI 1.53-10.02, p = 0.01].

Keywords: Adherence; Behavioural trial; Clinical trial; Loss to follow up; Mindfulness; Taichi/Qigong; Waitlist control.

Factors related to dropout in integrative oncology clinical trials: interim analysis of an ongoing comparative effectiveness trial of mindfulness-based cancer recovery and Tai chi/Qigong for cancer health (The MATCH study)