Author: Keller M1, Pelz H2, Perlitz V3, Zweerings J1, Röcher E1, Baqapuri HI1, Mathiak K1,4
Affiliation: <sup>1</sup>Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School, RWTH Aachen University, Aachen, Germany.
<sup>2</sup>Deutsche Gesellschaft für Osteopathische Medizin (DGOM), Mannheim, Germany.
<sup>3</sup>Simplana GmbH, Aachen, Germany.
<sup>4</sup>Jülich Aachen Research Alliance (JARA), Translational Brain Medicine, Jülich, Germany.
Conference/Journal: Psychophysiology.
Date published: 2020 May 10
Other:
Volume ID: e13594 , Special Notes: doi: 10.1111/psyp.13594. [Epub ahead of print] , Word Count: 201
Supratentorial brain structures such as the insula and the cingulate cortex modulate the autonomic nervous system (ANS). The neural underpinnings of separate frequency bands for variability in cardiac and respiratory data have been suggested in explaining parasympathetic and sympathetic ANS modulation. As an extension, an intermediate (IM) band in peripheral physiology has been considered to reflect psychophysiological states during rest. Using functional magnetic resonance imaging (fMRI), we investigated the neural correlates associated with IM band variability in cardiac and respiratory rate and identified dissociable networks for LF, IM, and HF bands in both modalities. Cardiac and respiratory IM band fluctuations correlated with blood oxygen level-dependent (BOLD) signal in the mid and posterior insula and the secondary somatosensory area, that is, regions related to interoceptive perception. These data suggest that in addition to the commonly considered LF and HF bands, other frequency components represent relevant physiological constituents. The IM band may be instrumental for assessment of the CNS-ANS interaction. In particular, the relation between the IM band and interoception may be of physiological and clinical interest.
© 2020 The Authors. Psychophysiology published by Wiley Periodicals LLC on behalf of Society for Psychophysiological Research.
KEYWORDS: autonomic regulation; depression; osteopathy; psychiatry; resting-state fMRI
PMID: 32390178 DOI: 10.1111/psyp.13594