Author: Murugan NJ1,2, Persinger MA1,3, Karbowski LM1, Dotta BT1,3
Affiliation: <sup>1</sup>Behavioural Neuroscience & Biomolecular Science, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.
<sup>2</sup>Department of Biology, Algoma University, Sault Ste. Marie, ON P6A 2G4, Canada.
<sup>3</sup>Department of Biology, Laurentian University, Sudbury, ON P3E 2C6, Canada.
Conference/Journal: Cancers (Basel).
Date published: 2020 Apr 18
Other:
Volume ID: 12 , Issue ID: 4 , Special Notes: doi: 10.3390/cancers12041001. , Word Count: 227
Early detection of cancer improves treatment options and increases survival. Building upon previous demonstrations that ultraweak photon emissions (UPE) could be measured to detect cancers, we designed an early detection protocol to test malignancy in both in vitro and in vivo systems. Photons were measured for 100 s from plates containing ~1 million malignant or non-malignant cells from 13 different types of human and mouse cell lines. Tumor cells displayed increased photon emissions compared to non-malignant cells. Examining the standardized Spectral Power Density (SPD) configurations for flux densities between 0.1 and 25 Hz (Δf = 0.01 Hz) yielded 90% discriminant accuracy. The emission profiles of mice that had been injected with melanoma cells could be differentiated from a non-malignant reference groups as early as 24 h post-injection. The peak SPD associated with photon emissions was ~20 Hz for both malignant cell cultures and mice with growing tumors. These results extend the original suggestion by Takeda and his colleagues (2004) published in this journal concerning the potential diagnostic value of UPEs for assessing proliferations of carcinoma cells. The specificity of the spectral profile in the 20 Hz range may be relevant to the consistent efficacy reported by several authors that weak magnetic field pulsations within this frequency range can diminish the growth of malignant cells in culture and tumor weights in mice.
KEYWORDS: cancer diagnostics; discriminant functions; malignancy; mice developing tumors; pancreatic cell cultures; ultraweak photon emission
PMID: 32325697 DOI: 10.3390/cancers12041001