A Systematic Review of Biological Mechanisms and Chronic Pain Outcomes During Stress Reduction Interventions.

Author: Bernier Carney KM1, Young EE2, Guite JW3, Starkweather AR4
Affiliation: <sup>1</sup>College of Nursing, University of Utah, Salt Lake City, UT, USA. <sup>2</sup>Department of Anesthesiology, University of Kansas School of Medicine, Kansas City, KS, USA. <sup>3</sup>Center for Advancement in Managing Pain Affiliate, School of Nursing, University of Connecticut, Storrs, CT, USA. <sup>4</sup>School of Nursing, University of Connecticut, Storrs, CT, USA.
Conference/Journal: Biol Res Nurs.
Date published: 2020 Apr
Other: Volume ID: 22 , Issue ID: 2 , Pages: 205-216 , Special Notes: doi: 10.1177/1099800420907964. , Word Count: 273


BACKGROUND: Nonpharmacologic stress reduction interventions provide an opportunity to modify chronic pain trajectories; however, the biological mechanisms underlying these interventions are poorly understood.

OBJECTIVES: To examine clinical literature published in 2012-2018 with the goals of (1) identifying which biological mechanisms or biomarkers are currently being measured in nonpharmacologic stress reduction intervention studies for individuals with chronic pain and (2) evaluating the evidence to determine whether these stress reduction interventions lead to changes in (a) pain outcomes and/or (b) measured biomarkers.

DATA SOURCES: Scientific articles in the electronic databases PubMed/Medline, Cumulative Index of Nursing and Allied Health Literature, PsychINFO, and SCOPUS following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.

STUDY SELECTION: Randomized controlled trials and quasi-experimental studies that recruited subjects with a chronic pain condition, examined a relationship between a nonpharmacologic stress reduction intervention and pain-related outcome(s), and included measurement of a biomarker.

RESULTS: The 13 articles that met inclusion criteria spanned four nonpharmacologic stress reduction categories: mindfulness-based stress reduction, physical exercise, manual therapies, and biofeedback. Methods for studying biomarkers included measuring biological samples, neurological function, and autonomic control. Although all studies investigated both biological measures and pain outcomes, only three demonstrated an association between the biomarker(s) and pain-related outcomes.

CONCLUSIONS: The results of this review highlight the complex nature of stress-pain relationships and the lack of rigorous clinical research identifying specific stress-related biological factors that modulate pain outcomes. Stress reduction interventions remain a favorable method for symptom management in patients living with chronic pain, but consistency in study measures and design is needed for robust evaluation.

KEYWORDS: biomarkers; chronic pain; nonpharmacologic intervention; psychological stress; stress reduction intervention

PMID: 32174159 DOI: 10.1177/1099800420907964