Author: Kim E1, Anguluan E2, Youn S3, Kim J3, Hwang JY3, Kim JG4
Affiliation: <sup>1</sup>School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
<sup>2</sup>Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
<sup>3</sup>Department of Information and Communication Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, 42988, Republic of Korea.
<sup>4</sup>Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea. jaekim@gist.ac.kr.
Conference/Journal: BMC Neurosci.
Date published: 2019 Mar 18
Other:
Volume ID: 20 , Issue ID: 1 , Pages: 12 , Special Notes: doi: 10.1186/s12868-019-0493-9. , Word Count: 167
BACKGROUND: Transcranial focused ultrasound (tFUS) attracts wide attention in neuroscience as an effective noninvasive approach to modulate brain circuits. In spite of this, the effects of tFUS on the brain is still unclear, and further investigation is needed. The present study proposes to use near-infrared spectroscopy (NIRS) to observe cerebral hemodynamic change caused by tFUS in a noninvasive manner.
RESULTS: The results show a transient increase of oxyhemoglobin and decrease of deoxyhemoglobin concentration in the mouse model induced by ultrasound stimulation of the somatosensory cortex with a frequency of 8 MHz but not in sham. In addition, the amplitude of hemodynamics change can be related to the peak intensity of the acoustic wave.
CONCLUSION: High frequency 8 MHz ultrasound was shown to induce hemodynamic changes measured using NIRS through the intact mouse head. The implementation of NIRS offers the possibility of investigating brain response noninvasively for different tFUS parameters through cerebral hemodynamic change.
KEYWORDS: Cerebral hemodynamics; Near-infrared spectroscopy; Ultrasound brain stimulation
PMID: 30885121 PMCID: PMC6423784 DOI: 10.1186/s12868-019-0493-9