Author: Sengupta S1,2, Balla VK1,2
Affiliation: <sup>1</sup>Bioceramics and Coating Division, CSIR-Central Glass and Ceramic Research Institute, 196 Raja S.C. Mullick Road, Kolkata 700032, India.
<sup>2</sup>Academy of Scientific and Innovative Research (AcSIR), CSIR-Central Glass and Ceramic Research Institute Campus, 196 Raja S.C. Mullick Road, Kolkata 700032, India.
Conference/Journal: J Adv Res.
Date published: 2018 Jun 20
Other:
Volume ID: 14 , Pages: 97-111 , Special Notes: doi: 10.1016/j.jare.2018.06.003. eCollection 2018 Nov. , Word Count: 200
Current popular cancer treatment options, include tumor surgery, chemotherapy, and hormonal treatment. These treatments are often associated with some inherent limitations. For instances, tumor surgery is not effective in mitigating metastases; the anticancer drugs used for chemotherapy can quickly spread throughout the body and is ineffective in killing metastatic cancer cells. Therefore, several drug delivery systems (DDS) have been developed to target tumor cells, and release active biomolecule at specific site to eliminate the side effects of anticancer drugs. However, common challenges of DDS used for cancer treatment, include poor site-specific accumulation, difficulties in entering the tumor microenvironment, poor metastases and treatment efficiency. In this context, non-invasive cancer treatment approaches, with or without DDS, involving the use of light, heat, magnetic field, electrical field and ultrasound appears to be very attractive. These approaches can potentially improve treatment efficiency, reduce recovery time, eliminate infections and scar formation. In this review we focus on the effects of magnetic fields and ultrasound on cancer cells and their application for cancer treatment in the presence of drugs or DDS.
KEYWORDS: Cancer; High intensity focused ultrasound (HIFU); Hyperthermia; Low intensity focused ultrasound (LIPUS); Pulsed magnetic field; Static magnetic field
PMID: 30109147 PMCID: PMC6090088 DOI: 10.1016/j.jare.2018.06.003