Author: Azagury A1, Amar-Lewis E1, Yudilevitch Y2, Isaacson C3, Laster B3, Kost J4
Affiliation: <sup>1</sup>Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
<sup>2</sup>Department of Chemical Engineering, Sami Shamoon College of Engineering, Beer-Sheva, Israel.
<sup>3</sup>Department of Nuclear Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
<sup>4</sup>Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address: kost@bgu.ac.il.
Conference/Journal: Ultrasound Med Biol.
Date published: 2016 Jul
Other:
Volume ID: 42 , Issue ID: 7 , Pages: 1560-7 , Special Notes: doi: 10.1016/j.ultrasmedbio.2016.02.005. Epub 2016 Apr 8. , Word Count: 180
Previous studies have found that cancer cells whose metastatic potential is low are more vulnerable to mechanical stress-induced trauma to their cytoskeleton compared with benign cells. Because ultrasound induces mechanical stresses on cells and tissues, it is postulated that there may be a way to apply ultrasound to tumors to reduce their ability to metastasize. The difference between low-malignant-potential cancer cells and benign cells could be a result of their different responses to the mechanical stress insonation induced. This hypothesis was tested in vitro and in vivo. Low-malignant-potential cells were found to be more sensitive to insonation, resulting in a significantly higher mortality rate compared with that of benign cells, 89% versus 21%, respectively. This effect can be controlled by varying ultrasound parameters: intensity, duration, and duty cycle. Thus, the results presented in this study suggest the application of ultrasound to discriminate between benign and malignant cells.
Copyright © 2016 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
KEYWORDS: Cancer cells; Cancer treatment strategy; In vivo experiments; Ultrasound; Ultrasound effect on biological membrane
PMID: 27067417 DOI: 10.1016/j.ultrasmedbio.2016.02.005