Author: Loprinzi PD1, Loenneke JP2
Affiliation: 1 a Physical Activity Epidemiology Laboratory, Exercise Psychology Laboratory, Department of Health, Exercise Science and Recreation Management , The University of Mississippi , University , MS , USA.
2 b Kevser Ermin Applied Physiology Laboratory, Department of Health, Exercise Science, and Recreation Management , The University of Mississippi , University , MS , USA.
Conference/Journal: J Sports Sci.
Date published: 2017 Feb 17
Other:
Volume ID: 1-7 , Special Notes: doi: 10.1080/02640414.2017.1293280. [Epub ahead of print] , Word Count: 167
The purpose of this study was to examine the association between leukocyte telomere length (LTL) and mortality (outcome variable), with consideration by physical activity behaviour. Data from the 1999-2002 National Health and Nutrition Examination Survey were employed (N = 6,611; 20-85 yrs), with follow-up mortality assessment through 31 December 2006. DNA was extracted from whole blood to assess LTL via quantitative polymerase chain reaction. Compared to those in the first LTL tertile, the adjusted hazard ratio for all-cause mortality for those in the 2nd and 3rd LTL tertiles, respectively, was 0.82 (95% CI: 0.60-1.12; P = .22) and 0.76 (95% CI: 0.50-1.14; P = .18). However, after adjustments, LTL tertile 3 (vs. 1) was associated with all-cause mortality (HR = 0.37; 95% CI: 0.14-0.93; P = .03) for those who engaged in moderate-intensity exercise. Similarly, LTL was associated with CVD-specific mortality for those who engaged in moderate-intensity exercise (HR = 0.17; 95% CI: 0.04-0.73; P = .02). Longer telomeres are associated with increased survival, particularly among men and those who are active, underscoring the importance of promotion of physical activity behaviour.
KEYWORDS: Aging; apoptosis; epidemiology; exercise; genomic integrity; survival
PMID: 28282748 DOI: 10.1080/02640414.2017.1293280