Author: Bilgin HM1, Çelik F1, Gem M2, Akpolat V3, Yıldız İ4, Ekinci A5, Özerdem MS6, Tunik S7
Affiliation: <sup>1</sup>Department of Physiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey. <sup>2</sup>Orthopedics and Traumatology, Dicle University, Diyarbakir, Turkey. <sup>3</sup>Biophysics, Dicle University, Diyarbakir, Turkey. <sup>4</sup>Biostatistics, Dicle University, Diyarbakir, Turkey. <sup>5</sup>Biochemistry, Dicle University, Diyarbakir, Turkey. <sup>6</sup>Department of Electrical & Electronics Engineering, Faculty of Engineering, Dicle University, Diyarbakir, Turkey. <sup>7</sup>Histology and Embryology, Dicle University, Diyarbakir, Turkey.
Date published: 2017 Feb 25
Other: Special Notes: doi: 10.1002/bem.22043. [Epub ahead of print] , Word Count: 206
The effectiveness of various therapeutic methods on bone fracture has been demonstrated in several studies. In the present study, we tried to evaluate the effect of local low-magnitude, high-frequency vibration (LMHFV) on rat tibia fracture in comparison with pulsed electromagnetic fields (PEMF) during the healing process. Mid-diaphysis tibiae fractures were induced in 30 Sprague-Dawley rats. The rats were assigned into groups such as control (CONT), LMHFV (15 min/day, 7 days/week), and PEMF (3.5 h/day, 7 days/week) for a three-week treatment. Nothing was applied to control group. Radiographs, serum osteocalcin levels, and stereological bone analyses of the three groups were compared. The X-rays of tibiae were taken 21 days after the end of the healing process. PEMF and LMHFV groups had more callus formation when compared to CONT group; however, the difference was not statistically significant (P = 0.375). Serum osteocalcin levels were elevated in the experimental groups compared to CONT (P ≤ 0.001). Stereological tests also showed higher osteogenic results in experimental groups, especially in LMHFV group. The results of the present study suggest that application of direct local LMHFV on fracture has promoted bone formation, showing great potential in improving fracture outcome. Bioelectromagnetics. © 2017 Wiley Periodicals, Inc.
© 2017 Wiley Periodicals, Inc.
KEYWORDS: fracture healing; pulsed electromagnetic field; rats; tibia; vibration
PMID: 28236321 DOI: 10.1002/bem.22043