Author: Harrison A1, Lin S2, Pounder N3, Mikuni-Takagaki Y4
Affiliation: <sup>1</sup>Bioventus Cooperatief, Amsterdam, Netherlands. Electronic address: andrew.harrison@bioventusglobal.com.
<sup>2</sup>Department of Orthopedics, Rutgers, New Jersey Medical School, USA.
<sup>3</sup>Bioventus LLC, Durham, NC, USA.
<sup>4</sup>Kanagawa Dental University, Graduate School of Dentistry, Yokosuka, Japan.
Conference/Journal: Ultrasonics.
Date published: 2016 Apr 9
Other:
Volume ID: 70 , Pages: 45-52 , Special Notes: doi: 10.1016/j.ultras.2016.03.016. [Epub ahead of print] , Word Count: 225
It has been 30years since the first level one clinical trial demonstrated low intensity pulsed ultrasound (LIPUS) could accelerate fracture repair. Since 1994 numerous investigations have been performed on the effect of LIPUS. The majority of these studies have used the same signal parameters comprised of an intensity of 30mW/cm2 SATA, an ultrasound carrier frequency of 1.5MHz, pulsed at 1kHz with an exposure time of 20minutes per day. These studies show that a biological response is stimulated in the cell which produces bioactive molecules. The production of these molecules, linked with observations demonstrating the enhanced effects on mineralization by LIPUS, might be considered the general manner, or mode, of how LIPUS stimulates fractures to heal. We propose a mechanism for how the LIPUS signal can enhance fracture repair by combining the findings of numerous studies. The LIPUS signal is transmitted through tissue to the bone, where cells translate this mechanical signal to a biochemical response via integrin mechano-receptors. The cells enhance the production of cyclo-oxygenese 2 (COX-2) which in turn stimulates molecules to enhance fracture repair. The aim of this review is to present the state of the art data related to LIPUS effects and mechanism.
Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
KEYWORDS: Bone morphogenic protein; Cyclo-oxygenase 2; Fracture; LIPUS; Mechanism; Ultrasound
PMID: 27130989 [PubMed - as supplied by publisher] Free full text