Author: Kaushik A1, Jayant RD, Sagar V, Nair M.
Affiliation: 1Florida International University, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Center of Personalized Nanomedicine, Department of Immunology , Miami, FL-33199 , USA.
Conference/Journal: Expert Opin Drug Deliv.
Date published: 2014 Oct
Other:
Volume ID: 11 , Issue ID: 10 , Pages: 1635-46 , Special Notes: doi: 10.1517/17425247.2014.933803 , Word Count: 209
Abstract
INTRODUCTION:
The development and design of personalized nanomedicine for better health quality is receiving great attention. In order to deliver and release a therapeutic concentration at the target site, novel nanocarriers (NCs) were designed, for example, magneto-electric (ME) which possess ideal properties of high drug loading, site-specificity and precise on-demand controlled drug delivery.
AREAS COVERED:
This review explores the potential of ME-NCs for on-demand and site-specific drug delivery and release for personalized therapeutics. The main features including effect of magnetism, improvement in drug loading, drug transport across blood-brain barriers and on-demand controlled release are also discussed. The future directions and possible impacts on upcoming nanomedicine are highlighted.
EXPERT OPINION:
Numerous reports suggest that there is an urgent need to explore novel NC formulations for safe and targeted drug delivery and release at specific disease sites. The challenges of formulation lie in the development of NCs that improve biocompatibility and surface modifications for optimum drug loading/preservation/transmigration and tailoring of electrical-magnetic properties for on-demand drug release. Thus, the development of novel NCs is anticipated to overcome the problems of targeted delivery of therapeutic agents with desired precision that may lead to better patient compliance.
KEYWORDS:
drug delivery; magneto-electric nanocarriers; nanocarriers; therapeutic agent nano particles nano medicine sanoscale
PMID: 24986772