Author: Karlseder J.
Affiliation: The Salk Institute, La Jolla, California 92037, USA karlseder@salk.edu.
Conference/Journal: Genes Dev.
Date published: 2014 Sep 1
Other:
Volume ID: 28 , Issue ID: 17 , Pages: 1857-1858 , Word Count: 69
Abstract
The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation and definition of telomere length homeostasis.
© 2014 Karlseder; Published by Cold Spring Harbor Laboratory Press.
KEYWORDS:
embryonic stem cells; human genome engineering; shelterin; telomerase; telomere maintenance
PMID: 25184673