Author: Renoir T1, Hasebe K2, Gray L2.
Affiliation: 1Melbourne Brain Centre, Florey Institute of Neuroscience and Mental Health, University of Melbourne Melbourne, VIC, Australia. 2School of Medicine, Deakin University Geelong, VIC, Australia.
Conference/Journal: Front Pharmacol.
Date published: 2013 Dec 18
Other:
Volume ID: 4 , Pages: 158 , Word Count: 188
It has long been established in traditional forms of medicine and in anecdotal knowledge that the health of the body and the mind are inextricably linked. Strong and continually developing evidence now suggests a link between disorders which involve Hypothalamic-Pituitary-Adrenal axis (HPA) dysregulation and the risk of developing psychiatric disease. For instance, adverse or excessive responses to stressful experiences are built into the diagnostic criteria for several psychiatric disorders, including depression and anxiety disorders. Interestingly, peripheral disorders such as metabolic disorders and cardiovascular diseases are also associated with HPA changes. Furthermore, many other systemic disorders associated with a higher incidence of psychiatric disease involve a significant inflammatory component. In fact, inflammatory and endocrine pathways seem to interact in both the periphery and the central nervous system (CNS) to potentiate states of psychiatric dysfunction. This review synthesizes clinical and animal data looking at interactions between peripheral and central factors, developing an understanding at the molecular and cellular level of how processes in the entire body can impact on mental state and psychiatric health.
KEYWORDS:
HPA axis, inflammatory processes, mind-body interactions, mood disorders, peripheral disorders, psychiatric diseases, stress response
PMID: 24385966