[Development of studies on bioeffects of ultrasound-acupuncture therapy and its underlying mechanism]. Author: Yang YH, Zhang D, Sa ZY, Huang M, Ding GH. Affiliation: Department of Mechanics and Engineering Science of Fudan University, Shanghai Research Center for Acupuncture and Meridians, Shanghai 200433, China. 10210290019@fudan.edu.cn Conference/Journal: Zhen Ci Yan Jiu. Date published: 2012 Aug Other: Volume ID: 37 , Issue ID: 4 , Special Notes: [Article in Chinese] , Word Count: 190 The so-called ultrasound acupuncture is a therapeutic approach for clinical problems and health care by applying the ultrasound energy to the acupoints of the human body directly or indirectly. It has been applied in clinic for about 30 years since 1980s. In the present paper, the authors review the development of both experimental and clinical researches in the past 30 years. Its clinical application includes allergic rhinitis, local pain, mastitis, angina pectoris of coronary heart disease, stroke, etc. Regarding the researches on the underlying mechanism of ultrasound and ultrasound acupuncture, the authors make a summary from 1) bioeffects (thermal and nonthermal effects) of ultrasound intervention; 2) cell lysis and nonlysis effects of ultrasound intervention; and 3) effects of ultrasound acupuncture on the degranulation of mast cells. Based on the idea that "inflammatory reaction caused by mast cell degranulation is one of the initial factors of acupuncture for inducing therapeutic effects", bioeffects including cellular changes, especially mast cell degranulation caused by ultrasound stimulation, are thought to be the main possible mechanisms underlying the favorable efficacy of ultrasound acupuncture intervention. However, the ultrasound metrology and the specific superiority of ultrasound acupuncture remain unknown up to now. PMID: 23140058