Proteomics and its application in the research of acupuncture: An updated review


Author: Zhen Zhong1, Meng-Meng Sun1, Min He1, Hai-Peng Huang1, Guan-Yu Hu2, Shi-Qi Ma1, Hai-Zhu Zheng1, Meng-Yuan Li1, Lin Yao1, De-Yu Cong3, Hong-Feng Wang1

Affiliation: <sup>1</sup> Changchun University of Chinese Medicine, No.1035 Boshuo Road, Jingyue National High Tech Industrial Development Zone, 130117, Changchun, China.

<sup>2</sup> The Third Affiliated Hospital of Southern Medical University, No.183, West of Zhongshan Avenue, Tianhe District, Guangzhou, 510630, Guangdong Province, China.

<sup>3</sup> Department of Tuina, Traditional Chinese Medicine Hospital of Jilin Province, 130000, Changchun, China.
Conference/Journal: Heliyon
Date published: 2024 Jun 18
Other:
 Volume ID: 10   ,  Issue ID: 12   ,  Pages: e33233   ,  Special Notes: doi: 10.1016/j.heliyon.2024.e33233.   ,  Word Count: 146  
    As a complementary and alternative therapy, acupuncture is widely used in the prevention and treatment of various diseases. However, the understanding of the mechanism of acupuncture effects is still limited due to the lack of systematic biological validation. Notably, proteomics technologies in the field of acupuncture are rapidly evolving, and these advances are greatly contributing to the research of acupuncture. In this study, we review the progress of proteomics research in analyzing the molecular mechanisms of acupuncture for neurological disorders, pain, circulatory disorders, digestive disorders, and other diseases, with an in-depth discussion around acupoint prescription and acupuncture manipulation modalities. The study found that proteomics has great potential in understanding the mechanisms of acupuncture. This study will help explore the mechanisms of acupuncture from a proteomic perspective and provide information to support future clinical decisions.



Keywords: Acupoints; Acupuncture; Electroacupuncture; Proteomics.



PMID: 39022010 PMCID: PMC11253069 DOI: 10.1016/j.heliyon.2024.e33233