Complementary and Integrative Medicine in Treating Headaches, Cognitive Dysfunction, Mental Fatigue, Insomnia, and Mood Disorders Following Traumatic Brain Injury: A Comprehensive Review Author: Bruno Subbarao1, Zayd Hayani2, Zeke Clemmens2 Affiliation: <sup>1</sup> Wellness and Administrative Medicine, Phoenix Veterans Healthcare System, 650 East Indian School Road, Phoenix, AZ 85012, USA. Electronic address: bruno.subbarao@va.gov. <sup>2</sup> HonorHealth, 8850 East Pima Center Parkway, Scottsdale, AZ 85258, USA. Conference/Journal: Phys Med Rehabil Clin N Am Date published: 2024 Aug 1 Other: Volume ID: 35 , Issue ID: 3 , Pages: 651-664 , Special Notes: doi: 10.1016/j.pmr.2024.02.013. , Word Count: 121 Traumatic brain injury (TBI) is a complex condition associated with a range of persistent symptoms including headaches, cognitive dysfunction, mental fatigue, insomnia, and mood disorders. Conventional treatments for TBI-related symptoms can be insufficient, leading to interest in complementary and integrative medicine (CIM) approaches. This comprehensive article examines the existing literature on CIM modalities, including mind-body interventions, acupuncture/acupressure, herbal remedies, nutritional supplements, biofeedback, yoga, and tai chi in the context of managing secondary complications following TBI. The article highlights potential benefits and limitations of CIM modalities, while acknowledging the need for further research to better establish efficacy and safety in this specific population. Keywords: Acupuncture; Biofeedback; Complementary integrative medicine; Mindfulness; Supplements; Tai chi; Traumatic brain injury; Yoga. PMID: 38945657 DOI: 10.1016/j.pmr.2024.02.013