Effects of a Tai Chi rehabilitation program implemented using a hybrid online and offline mode on oxidative stress and inflammatory responses in patients with coronary heart disease: a randomized controlled trial


Author: Meize Cui#1, Qiuyang Wei#2, Yameng Li3, Mingyu Liu1, Ligang Sun4, Xinyi Liu4, Zaihao Chen1, Hui Fang1, Linli Liu5, Jiahao Fu6, Cuihan Li1, Haojie Li1, Yuxin Ma1, Xing Zhang1, Yuerong Huang1, Lujia Li1, Shaojun Lyu1, Jianwei Zhang1

Affiliation: <sup>1</sup> College of Physical Education and Sports, Beijing Normal University, Beijing, China.

<sup>2</sup> Sports Department, Jiangsu University, Zhenjiang, Jiangsu, China.

<sup>3</sup> Department of Physical Education, Northwestern Polytechnical University, Xi'an, China.

<sup>4</sup> University Hospital, Beijing Normal University, Beijing, China.

<sup>5</sup> China University of Labor Relations, Beijing, China.

<sup>6</sup> Zhejiang Guangsha Vocational and Technical University of Construction, Zhejiang, China.
Conference/Journal: Front Public Health
Date published: 2024 May 17
Other:
 Volume ID: 12   ,  Pages: 1369675   ,  Special Notes: doi: 10.3389/fpubh.2024.1369675.   ,  Word Count: 327  
    Background:

Coronary heart disease (CHD) is the leading cause of death in both developed and many developing countries. Exercise training is a fundamental component of cardiac rehabilitation programs for patients with CHD. This study aims to investigate the effects of a Tai Chi rehabilitation program, which is provided through a hybrid online and offline mode, on oxidative stress and inflammatory responses in patients with CHD.



Methods:

A total of 34 patients with coronary heart disease were randomly assigned to two groups: an experiment group (n = 14, age 62.07 ± 9.076 years) and a control group (n = 20, age 61.90 ± 9.700 years). The experiment group underwent a 12-week Tai Chi cardiac rehabilitation program (TCCRP), while the control group followed a conventional exercise rehabilitation program (CERP) consisting of 1-h sessions, 3 times per week, for a total of 36 sessions. Participants were studied at baseline and post-intervention. The main assessments include the levels of Malondialdehyde (MDA), Superoxide dismutase (SOD), Tumor necrosis factor (TNF-α) and Interleukin-10 (IL - 10) in blood samples. Pearson correlation analysis was used, and the differences between the two groups were subsequently tested using two-way repeated ANOVA. Statistical significance was defined as a two-sided p-value of <0.05.



Results:

The key finding of the study reveals that MDA was significantly reduced by 1.027 nmoL/mL. Additionally, the TCCRP showed significant improvements in SOD and IL-10, with values of 10.110 U/mL and 2.441 pg./mL, respectively. Notably, a significant positive correlation was found between SOD and IL-10 (r = 0.689, p = 0.006), while MDA showed a significant positive correlation with TNF-a (r = 0.542, p = 0.045). In contrast, the ECRP group only showed a significant improvement in SOD.



Conclusion:

The study conducted a 12-week program on TCCRP, which utilized a hybrid online and offline model for individuals with coronary heart disease. The program showed promising results in alleviating oxidative stress and inflammation, possibly by regulating the balance between oxidative and antioxidative factors, as well as pro-inflammatory and anti-inflammatory factors.



Keywords: Tai Chi; coronary heart disease; inflammatory response; oxidative stress; randomized controlled trial.



PMID: 38827614 PMCID: PMC11140728 DOI: 10.3389/fpubh.2024.1369675