Can strength training or tai ji quan training reduce frailty in postmenopausal women treated with chemotherapy? A secondary data analysis of the GET FIT trial Author: Kerri M Winters-Stone1,2, Sydnee A Stoyles3, Nathan F Dieckmann3, Elizabeth Eckstrom4, Shiuh-Wen Luoh5,6, Fay B Horak7, Eric J Roeland5, Fuzhong Li8 Affiliation: <sup>1</sup> Division of Oncological Sciences, Oregon Health &amp; Science University, Portland, OR, 97239, USA. wintersk@ohsu.edu. <sup>2</sup> Knight Cancer Institute, Oregon Health &amp; Science University, Portland, OR, 97239, USA. wintersk@ohsu.edu. <sup>3</sup> School of Nursing, Oregon Health &amp; Science University, Portland, OR, 97239, USA. <sup>4</sup> Division of General Internal Medicine &amp; Geriatrics, Oregon Health &amp; Science University, Portland, OR, 97239, USA. <sup>5</sup> Knight Cancer Institute, Oregon Health &amp; Science University, Portland, OR, 97239, USA. <sup>6</sup> Portland Veteran&#x27;s Affairs Medical Center, Portland, OR, 97239, USA. <sup>7</sup> Department of Neurology, School of Medicine, Oregon Health &amp; Science University, Portland, OR, 97239, USA. <sup>8</sup> Oregon Research Institute, Springfield, OR, 97477, USA. Conference/Journal: J Cancer Surviv Date published: 2024 Apr 20 Other: Special Notes: doi: 10.1007/s11764-024-01592-5. , Word Count: 309 Purpose: To determine whether strength training or tai ji quan can reduce frailty in older, postmenopausal women treated with chemotherapy for cancer. Methods: We conducted a secondary data analysis from a 3-arm, single-blind, randomized controlled trial where older (50-75 years), postmenopausal women cancer survivors were randomized to supervised group exercise programs: tai ji quan, strength training, or stretching control for 6 months. We assessed frailty using a 4-criteria model consisting of weakness, fatigue, inactivity, and slowness. Using logistic regression, we determined whether the frailty phenotype (pre-frailty or frailty) decreased post-intervention, how many and which frailty criteria decreased, and what characteristics identified women most likely to reduce frailty. Results: Data from 386 women who completed baseline and 6-month testing were used (mean age of 62.0 ± 6.4 years). The odds of reducing overall frailty over 6 months were significantly higher in the strength training group compared to controls (OR [95%CI] 1.86 [1.09, 3.17]) but not for tai ji quan (1.44 [0.84, 2.50]). Both strength training (OR 1.99 [1.10, 3.65]) and tai ji quan (OR 2.10 [1.16, 3.84]) led to significantly higher odds of reducing ≥ 1 frailty criterion compared to controls. Strength training led to a three-fold reduction in inactivity (p < 0.01) and tai ji quan to a two-fold reduction in fatigue (p = 0.08) versus control. Higher baseline BMI, comorbidity score, and frailty status characterized women were more likely to reduce frailty than other women. Conclusions: Strength training appears superior to tai ji quan and stretching with respect to reducing overall frailty phenotype among postmenopausal women treated with chemotherapy for cancer, but tai ji quan favorably reduced the number of frailty criteria. Trial registration: ClinicalTrials.gov identifier: GET FIT was registered as a clinical trial in clinicaltrials.gov: NCT01635413. Implications for cancer survivors: Supervised, group exercise training that emphasizes strength training and/or tai ji quan may help combat accelerated aging and reduce frailty after cancer treatment. Keywords: Aging; Exercise; Neoplasm; Physical activity; Physical functioning. PMID: 38642204 DOI: 10.1007/s11764-024-01592-5