Neural circuits regulating visceral pain


Author: Xiaoli Chang1,2, Haiyan Zhang3, Shaozong Chen4

Affiliation: <sup>1</sup> College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. changxiaoli2017@163.com.

<sup>2</sup> Research Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. changxiaoli2017@163.com.

<sup>3</sup> Research Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.

<sup>4</sup> Research Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. ccsz1963@163.com.
Conference/Journal: Commun Biol
Date published: 2024 Apr 13
Other:
 Volume ID: 7   ,  Issue ID: 1   ,  Pages: 457   ,  Special Notes: doi: 10.1038/s42003-024-06148-y.   ,  Word Count: 111  
    Visceral hypersensitivity, a common clinical manifestation of irritable bowel syndrome, may contribute to the development of chronic visceral pain, which is a major challenge for both patients and health providers. Neural circuits in the brain encode, store, and transfer pain information across brain regions. In this review, we focus on the anterior cingulate cortex and paraventricular nucleus of the hypothalamus to highlight the progress in identifying the neural circuits involved in visceral pain. We also discuss several neural circuit mechanisms and emphasize the importance of cross-species, multiangle approaches and the identification of specific neurons in determining the neural circuits that control visceral pain.





PMID: 38615103 PMCID: PMC11016080 DOI: 10.1038/s42003-024-06148-y