Whole-Body Vibration Training on Oxidative Stress Markers, Irisin Levels, and Body Composition in Women with Fibromyalgia: A Randomized Controlled Trial Author: Jousielle Márcia Dos Santos1,2, Redha Taiar3, Vanessa Gonçalves César Ribeiro1, Vanessa Kelly da Silva Lage1, Pedro Henrique Scheidt Figueiredo2, Henrique Silveira Costa2, Vanessa Pereira Lima2, Borja Sañudo4, Mário Bernardo-Filho5, Danúbia da Cunha de Sá-Caputo5, Marco Fabrício Dias Peixoto1,6, Vanessa Amaral Mendonça1,2,6, Amandine Rapin7, Ana Cristina Rodrigues Lacerda1,2,6 Affiliation: <sup>1</sup> Multicenter Graduate Program in Physiological Sciences, Brazilian Society of Physiology, Diamantina 39100-000, Brazil. <sup>2</sup> Graduate Program in Functional Performance and Rehabilitation, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina 39100-000, Brazil. <sup>3</sup> MATériaux et Ingénierie Mécanique, Université de Reims Champagne Ardenne, 51100 Reims, France. <sup>4</sup> Department of Physical Education and Sports, Universidad de Sevilla, 41013 Seville, Spain. <sup>5</sup> Mechanical Vibration Laboratory and Integrative Practices, Department of Biophysics and Biometrics, Institute of Biology Roberto Alcântara Gomes and Piquet Carneiro Polyclinic, Rio de Janeiro State University, Rio de Janeiro 20950-003, Brazil. <sup>6</sup> Graduate Program in Health Sciences, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina 39100-00, Brazil. <sup>7</sup> Faculté de Médecine, Université de Reims Champagne Ardennes, UR 3797 VieFra, 51097 Reims, France. Conference/Journal: Bioengineering (Basel) Date published: 2023 Feb 16 Other: Volume ID: 10 , Issue ID: 2 , Pages: 260 , Special Notes: doi: 10.3390/bioengineering10020260. , Word Count: 220 (1) Background: Mitochondrial dysfunction and redox imbalance seem to be involved in fibromyalgia (FM) pathogenesis. The results of our previous studies suggest that whole-body vibration training (WBVT) would improve redox status markers, increase blood irisin levels, and ameliorate the body composition of women with FM. (2) Objective: The current study aimed to investigate WBVT on oxidative stress markers, plasma irisin levels, and body composition in women with FM. (3) Methods: Forty women with FM were randomized into WBVT or untrained (UN) groups. Before and after 6 weeks of WBVT, body composition was assessed by dual-energy radiological absorptiometry (DXA), and inflammatory marker activities were measured by enzymatic assay. (4) Results: Body composition, blood irisin levels, and oxidative stress markers were similar between UN and WBVT groups before the intervention. After 6 weeks of intervention, the WBVT group presented higher irisin levels (WBVT: 316.98 ± 109.24 mg·dL³, WBVT: 477.61 ± 267.92 mg·dL³, p = 0.01) and lower TBARS levels (UN: 0.39 ± 0.02 nmol MDA/mg protein, WBVT: 0.24 ± 0.06 nmol MDA/mg protein, p = 0.001) and visceral adipose tissue mass (UN: 1.37 ± 0.49 kg, WBVT: 0.69 ± 0.54 kg, p = 0.001) compared to the UN group. (5) Conclusions: Six weeks of WBVT improves blood redox status markers, increases irisin levels, and reduces visceral adipose tissue mass, favoring less cell damage and more outstanding oxidative balance in women with FM. Keywords: chronic condition; fibromyalgia; muscle pain; obesity; oxidative stress; visceral adipose tissue; whole-body vibration. PMID: 36829754 DOI: 10.3390/bioengineering10020260