Effect of Yoga and Mediational Influence of Fatigue on Walking, Physical Activity, and Quality of Life Among Cancer Survivors Author: Po-Ju Lin1, Brian J Altman2, Nikesha J Gilmore1, Kah Poh Loh3, Richard F Dunne3, Javier Bautista4, Chunkit Fung3, Michelle C Janelsins1, Luke J Peppone1, Marianne K Melnik5, Kim O Gococo6, Michael J Messino7, Karen M Mustian1 Affiliation: <sup>1</sup> 1Department of Surgery, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York. <sup>2</sup> 2Department of Biomedical Genetics, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York. <sup>3</sup> 3Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York. <sup>4</sup> 4Department of Mathematics, University of Rochester, Rochester, New York. <sup>5</sup> 5Cancer Research Consortium of West Michigan NCORP, Grand Rapids, Michigan. <sup>6</sup> 6NCORP of the Carolinas (Greenville Health System), Greenville, South Carolina. <sup>7</sup> 7Southeast Clinical Oncology Research Consortium NCORP, Winston Salem, North Carolina. Conference/Journal: J Natl Compr Canc Netw Date published: 2023 Feb 1 Other: Volume ID: 21 , Issue ID: 2 , Pages: 153-162e2 , Special Notes: doi: 10.6004/jnccn.2022.7080. , Word Count: 286 Background: Cancer-related fatigue (CRF) negatively affects survivors' walking, engagement in physical activity (PA), and quality of life (QoL). Yoga is an effective therapy for treating CRF; however, evidence from large clinical trials regarding how reducing CRF through yoga influences CRF's interference with survivors' walking, engagement in PA, and QoL is not available. We examined the effects of yoga and the mediational influence of CRF on CRF's interference with walking, PA, and QoL among cancer survivors in a multicenter phase III randomized controlled trial. Patients and methods: Cancer survivors (n=410) with insomnia 2 to 24 months posttreatment were randomized to a 4-week yoga intervention-Yoga for Cancer Survivors (YOCAS)-or standard care. A symptom inventory was used to assess how much CRF interfered with survivors' walking, PA, and QoL. The Multidimensional Fatigue Symptom Inventory-Short Form was used to assess CRF. Two-tailed t tests and analyses of covariance were used to examine within-group and between-group differences. Path analysis was used to evaluate mediational relationships between CRF and changes in CRF's interference with walking, PA, and QoL among survivors. Results: Compared with standard care controls, YOCAS participants reported significant improvements in CRF's interference with walking, PA, and QoL at postintervention (all effect size = -0.33; all P≤.05). Improvements in CRF resulting from yoga accounted for significant proportions of the improvements in walking (44%), PA (53%), and QoL (45%; all P≤.05). Conclusions: A significant proportion (44%-53%) of the YOCAS effect on CRF's interference with walking, PA, and QoL was due to improvements in CRF among cancer survivors. Yoga should be introduced and included as a treatment option for survivors experiencing fatigue. By reducing fatigue, survivors further improve their walking, engagement in PA, and QoL. Keywords: Cancer-related Fatigue; Physical Activity; Survivorship; Yoga; quality of life. PMID: 36791754 DOI: 10.6004/jnccn.2022.7080