A randomized controlled trial of Baduanjin exercise to reduce the risk of atherosclerotic cardiovascular disease in patients with prediabetes Author: Xiaojun Ma#1,2, Manlin Li#1, Lin Liu1, Fenfang Lei3,4, Liduo Wang1, Wenyan Xiao1, Yingzi Tan1, Binghua He5, Sijie Ruan6 Affiliation: <sup>1</sup> School of Nursing, Shaoyang University, Shaoyang, 422000, Hunan Province, China. <sup>2</sup> Graduate School, Adamson University, 0900, Manila, Philippines. <sup>3</sup> Graduate School, Guangxi Medical University, Nanning, 530022, Guangxi Zhuang Autonomous Region, China. <sup>4</sup> Department of Anesthesiology, Central Hospital of Shaoyang, Shaoyang City, 422000, Hunan Province, China. <sup>5</sup> Department of Anesthesiology, Central Hospital of Shaoyang, Shaoyang City, 422000, Hunan Province, China. 272138377@qq.com. <sup>6</sup> Department of Anesthesiology, Central Hospital of Shaoyang, Shaoyang City, 422000, Hunan Province, China. 2623398873@qq.com. Conference/Journal: Sci Rep Date published: 2022 Nov 11 Other: Volume ID: 12 , Issue ID: 1 , Pages: 19338 , Special Notes: doi: 10.1038/s41598-022-22896-5. , Word Count: 191 To investigate the effectiveness of long-term Baduanjin and aerobic training on the 10-year risk of atherosclerotic cardiovascular disease in prediabetic patients. This study was single-blind randomized controlled trial. A total of 98 participants with prediabetes were randomly divided into three groups: the BDJ (n = 34), AT (n = 32), and control (n = 32) groups. Participants in the BDJ and AT groups underwent one year of supervised group exercise, consisting of 60 min/session every other day. The primary outcomes were metabolic control and the 10-year risk of ASCVD. The secondary outcome was a change in blood glucose status. After the intervention, various metabolic indexes were significantly improved in the two exercise groups relative to the control group and baseline measurements (p < 0.05). Compared with no exercise, BDJ and AT had significant preventive and protective effects against the risk of ASCVD in patients with prediabetes (p < 0.001). The overall effects of the two exercise groups were similar (p > 0.05). Long-term BDJ training can effectively reduce the risk of type 2 diabetes mellitus (T2DM) and its cardiovascular complications in prediabetic patients. The effect of BDJ is similar to that of moderate-intensity aerobic exercise. PMID: 36369247 DOI: 10.1038/s41598-022-22896-5