The Effect of Reiki on Anxiety, Stress, and Comfort Levels Before Gastrointestinal Endoscopy: A Randomized Sham-Controlled Trial Author: Hediye Utli1, Birgül Vural Doğru2 Affiliation: <sup>1</sup> Department of Elderly Care, Vocational School of Health Services, Mardin Artuklu University, Mardin, Turkey. Electronic address: hediyeutli@artuklu.edu.tr. <sup>2</sup> Internal Medicine Nursing Department, Mersin University Faculty of Nursing, Mersin, Turkey. Conference/Journal: J Perianesth Nurs Date published: 2022 Oct 20 Other: Special Notes: doi: 10.1016/j.jopan.2022.08.010. , Word Count: 166 Purpose: This study's aim is to determine the effect of Reiki when applied before upper gastrointestinal endoscopy on levels of anxiety, stress, and comfort. Design: This single-blind, a pretest and post-test design, randomized, sham-controlled study was held between February and July 2021. Methods: Patients who met the inclusion criteria were separated by randomization into three groups: Reiki, sham Reiki, and control. A total of 159 patients participated in the study. In the intervention groups (Reiki and sham Reiki), Reiki and sham Reiki were applied once for approximately 20 to 25 minutes before gastrointestinal endoscopy. Findings: When the Reiki group was compared to the sham Reiki and control groups following the intervention, the decrease in the levels of patient stress (P < .001) and anxiety (P < .001) and the increase in patient comfort (P < .001) were found to be statistically significant. Conclusions: Reiki applied to patients before upper gastrointestinal endoscopy was effective in reducing stress and anxiety and in increasing comfort. Keywords: Reiki; anxiety; comfort; endoscopy; nursing; stress. PMID: 36272846 DOI: 10.1016/j.jopan.2022.08.010