The efficacy of Tai Chi for depression: A protocol for systematic review and meta-analysis Author: Guojian He1, Xiucai Zhang2, Ting Yan3, Jiayi Wang4, Qi Li3, Tianyu Liu3, Youn-Poong Oh5 Affiliation: <sup>1</sup> Physical Education Department, Hebei University of Economics and Business, Shijiazhuang, Hebei, China. <sup>2</sup> School of International Education, University of Electronic Science and Technology, Chengdu, Sichuan, China. <sup>3</sup> School of Sport, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. <sup>4</sup> Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. <sup>5</sup> Department of Physical Education, Kunsan National University, Gunsan, Korea. Conference/Journal: Medicine (Baltimore) Date published: 2022 Feb 4 Other: Volume ID: 101 , Issue ID: 5 , Pages: e28330 , Special Notes: doi: 10.1097/MD.0000000000028330. , Word Count: 212 Background: Depression is a commonly occurring and recurrent mental disorder cross the world. Tai Chi is a traditional Chinese mind-body exercise which could be used to treat mental disorders including depression. This study aimed to conduct a systematic review and meta-analysis to assess the efficiency of Tai Chi for patients with depression. Methods: This protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol statement. Literature will be searched at PubMed, EMBASE, Web of Science, Cochrane Library, China Biology Medicine Database, China National Knowledge Infrastructure, Technology Journal Database, and Wan Fang database from the start date to September 2021. The Review Manager 5.3 software will be used to manage literature. After literature screening, 2 reviewers will extract data from the respects of general information, methodology, and results. The data analysis will be conducted with Review Manager and Stata 16 software, and the publication bias and literature quality will be both evaluated. Results: The results will contain the evaluation of clinical efficacy of Tai Chi practice for depression, as well as the assessment of literature quality and publication bias. Conclusion: The current review will provide new evidence on whether and to what extent patients with depression can benefit from Tai Chi practice.Registration number: DOI: 10.17605/OSF.IO/AUDNQ (https://osf.io/audnq). PMID: 35119001 DOI: 10.1097/MD.0000000000028330