Geroscience: linking aging to chronic disease


Author: Brian K Kennedy1, Shelley L Berger2, Anne Brunet3, Judith Campisi4, Ana Maria Cuervo5, Elissa S Epel6, Claudio Franceschi7, Gordon J Lithgow8, Richard I Morimoto9, Jeffrey E Pessin10, Thomas A Rando11, Arlan Richardson12, Eric E Schadt13, Tony Wyss-Coray14, Felipe Sierra15

Affiliation: <sup>1</sup> Buck Institute for Research on Aging, Novato, CA USA. Electronic address: bkennedy@buckinstitute.org.

<sup>2</sup> Penn Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology and Department of Genetics and Department of Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

<sup>3</sup> Department of Genetics, Stanford University, Stanford, CA 94305, USA; Glenn Center for the Biology of Aging, Stanford University, Stanford, CA 94305, USA.

<sup>4</sup> Buck Institute for Research on Aging, Novato, CA USA; Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

<sup>5</sup> Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

<sup>6</sup> Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94143, USA.

<sup>7</sup> IRCCS Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy; C.I.G., Interdepartmental Center 'L. Galvani' for Integrated Studies on Bioinformatics, Biophysics, and Biocomplexity, University of Bologna, 3 Bologna, Italy; DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 3 Bologna, Italy.

<sup>8</sup> Buck Institute for Research on Aging, Novato, CA USA.

<sup>9</sup> Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA.

<sup>10</sup> Department of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

<sup>11</sup> Glenn Center for the Biology of Aging, Stanford University, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.

<sup>12</sup> Donald W Reynolds Endowed Chair of Aging Research, Professor of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA; Oklahoma City VA Medical Center, Oklahoma City, OK 73104, USA.

<sup>13</sup> Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences and the Icahn Institute for Genomics and Multiscale Biology, New York, NY 10029, USA.

<sup>14</sup> Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.

<sup>15</sup> Division of Aging Biology, National Institute on Aging, Bethesda, MD 20892, USA.
Conference/Journal: Cell
Date published: 2014 Nov 6
Other:
 Volume ID: 159   ,  Issue ID: 4   ,  Pages: 709-13   ,  Special Notes: doi: 10.1016/j.cell.2014.10.039.   ,  Word Count: 56  
    Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscience research directed at extending human healthspan.





PMID: 25417146 PMCID: PMC4852871 DOI: 10.1016/j.cell.2014.10.039