From many to (n)one:Meditation and the plasticity of the predictive mind Author: Ruben E Laukkonen1, Heleen A Slagter2 Affiliation: <sup>1</sup> Vrije Universiteit Amsterdam, Netherlands. Electronic address: r.e.laukkonen@vu.nl. <sup>2</sup> University of Amsterdam, Netherlands. Electronic address: h.a.slagter@vu.nl. Conference/Journal: Neurosci Biobehav Rev Date published: 2021 Jun 14 Other: Special Notes: doi: 10.1016/j.neubiorev.2021.06.021. , Word Count: 190 How profoundly can humans change their own minds? In this paper we offer a unifying account of deconstructive meditation under the predictive processing view. We start from simple axioms. First, the brain makes predictions based on past experience, both phylogenetic and ontogenetic. Second, deconstructive meditation brings one closer to the here and now by disengaging anticipatory processes. We propose that practicing meditation therefore gradually reduces counterfactual temporally deep cognition, until all conceptual processing falls away, unveiling a state of pure awareness. Our account also places three main styles of meditation (focused attention, open monitoring, and non-dual) on a single continuum, where each technique relinquishes increasingly engrained habits of prediction, including the predicted self. This deconstruction can also permit certain insights by making the above processes available to introspection. Our framework is consistent with the state of empirical and (neuro)phenomenological evidence and illuminates the top-down plasticity of the predictive mind. Experimental rigor, neurophenomenology, and no-report paradigms are needed to further understanding of how meditation affects predictive processing and the self. Keywords: Plasticity; attention; brain; consciousness; insight; meditation; non-dual awareness; predictive brain; predictive processing; sense of self. PMID: 34139248 DOI: 10.1016/j.neubiorev.2021.06.021