Effect of exercise on bone mineral density and quality of life among postmenopausal women with osteoporosis without fracture: A systematic review Author: D S Anupama1, Judith A Norohna2, Kiran Kv Acharya3, Ravishankar4, Anice George1 Affiliation: <sup>1</sup> Manipal College of Nursing, MAHE, Manipal, India. <sup>2</sup> Department of OBG nursing, Manipal college of Nursing, MAHE, Manipal, India. Electronic address: judith.n@manipal.edu. <sup>3</sup> Dept.of Orthopedics, Kasturba Hospital, Manipal, India. <sup>4</sup> Department of Statistics, Prasanna School of Public Health, MAHE, Manipal, India. Conference/Journal: Int J Orthop Trauma Nurs Date published: 2020 Jul 28 Other: Special Notes: doi: 10.1016/j.ijotn.2020.100796. , Word Count: 245 Background: Osteoporosis is a progressive disease commonly seen in postmenopausal women which is characterized by decreased bone mass. This is becoming an important public health issue in India. This review aimed to evaluate the effect of exercise on quality of life and bone health status among postmenopausal osteoporotic women. Methods: We searched the following databases: Pubmed-Medline, Proquest, CINAHL, Scopus, Cochrane Central and PEDro. The review included randomized controlled trials that examined the use of exercise aimed at improving bone mineral density and quality of life in postmenopausal osteoporotic women without a history of fracture. Risk of bias was assessed by the Cochrane Risk of Bias tool. Results: This review suggests exercise is effective in improving the bone mineral density and quality of life of postmenopausal women with osteoporosis. The exercise interventions included in the studies were heterogeneous and included: Tai Chi, high intensity aerobic exercises, Modified Eight Section Brocade exercises, progressive slow loading low impact exercises, pilates and closed kinetic exercises. Four studies had a small sample size and in three studies, interventions were for a shorter duration. Meta-analysis could not be performed as the studies were not homogenous. Conclusion: There is a need to conduct more experimental trials with robust research methods so that a high risk of bias can be avoided. The available evidence supports the positive effects of exercises on postmenopausal osteoporosis. Keywords: Bone health status; Bone mineral density; Exercises; Osteoporosis; Postmenopausal women; Quality of life; Systematic review. PMID: 33041224 DOI: 10.1016/j.ijotn.2020.100796