Tai Chi on bone mineral density of postmenopausal osteoporosis: A protocol for systematic review and meta-analysis Author: Hai-Yang Wu1, Yi-Ru Wang2, Guo-Wei Wen1, Zhen-Yin Tang1, Yi-Qun Yu1, Ji-Ren Zhang1, Ping Liu2, Jun-Hao Wu1 Affiliation: <sup>1</sup> Huangpu Branch, Shanghai Ninth People&#39;s Hospital affiliated to Shanghai Jiaotong University, Shanghai, China. <sup>2</sup> Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. Conference/Journal: Medicine (Baltimore) Date published: 2020 Sep 4 Other: Volume ID: 99 , Issue ID: 36 , Pages: e21928 , Special Notes: doi: 10.1097/MD.0000000000021928. , Word Count: 158 Background: Osteoporosis is a clinically common metabolic disease, especially in postmenopausal women. Tai Chi might be beneficial in osteoporosis patients. This study will be performed to examine the effects of Tai Chi on bone mineral density of postmenopausal osteoporosis. Methods: We will search the electronical databases and hand-searching journals or reference lists. The study screening and data extraction will be carried out by 2 investigators independently. The primary outcome is bone mineral density (lumbar spine, Ward's triangle, trochanter, proximal femur, femoral neck, or total hip). Secondary outcomes are pain score, alkaline phosphatase, osteocalcin, and adverse effects. Review Manager V.5.3 software will be used to compute the data. Results: The results of the study will provide a reliable evidence to assess the effects of Tai Chi on bone mineral density of postmenopausal osteoporosis. Conclusion: The conclusion of our systematic review will answer whether Tai Chi is an effective intervention to improve bone mineral density of postmenopausal osteoporosis. PMID: 32899027 DOI: 10.1097/MD.0000000000021928