The role of the gut microbiome in the development of schizophrenia. Author: Kelly JR1, Minuto C2, Cryan JF3, Clarke G4, Dinan TG5 Affiliation: <sup>1</sup>Department of Psychiatry, Trinity College Dublin, Ireland. <sup>2</sup>Department of Psychiatry and Neurobehavioral Science, University College Cork, Ireland. <sup>3</sup>APC Microbiome Ireland, University College Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Ireland. <sup>4</sup>Department of Psychiatry and Neurobehavioral Science, University College Cork, Ireland; APC Microbiome Ireland, University College Cork, Ireland. <sup>5</sup>Department of Psychiatry and Neurobehavioral Science, University College Cork, Ireland; APC Microbiome Ireland, University College Cork, Ireland. Electronic address: t.dinan@ucc.ie. Conference/Journal: Schizophr Res. Date published: 2020 Apr 23 Other: Pages: S0920-9964(20)30086-4 , Special Notes: doi: 10.1016/j.schres.2020.02.010. [Epub ahead of print] , Word Count: 218 Schizophrenia is a heterogeneous neurodevelopmental disorder involving the convergence of a complex and dynamic bidirectional interaction of genetic expression and the accumulation of prenatal and postnatal environmental risk factors. The development of the neural circuitry underlying social, cognitive and emotional domains requires precise regulation from molecular signalling pathways, especially during critical periods or "windows", when the brain is particularly sensitive to the influence of environmental input signalling. Many of the brain regions involved, and the molecular substrates sub-serving these domains are responsive to life-long microbiota-gut-brain (MGB) axis signalling. This intricate microbial signalling system communicates with the brain via the vagus nerve, immune system, enteric nervous system, enteroendocrine signalling and production of microbial metabolites, such as short-chain fatty acids. Preclinical data has demonstrated that MGB axis signalling influences neurotransmission, neurogenesis, myelination, dendrite formation and blood brain barrier development, and modulates cognitive function and behaviour patterns, such as, social interaction, stress management and locomotor activity. Furthermore, preliminary clinical studies suggest altered gut microbiota profiles in schizophrenia. Unravelling MGB axis signalling in the context of an evolving dimensional framework in schizophrenia may provide a more complete understanding of the neurobiological architecture of this complex condition and offers the possibility of translational interventions. Copyright © 2020 Elsevier B.V. All rights reserved. KEYWORDS: Gut-brain axis; Microbiome; Microbiota; Psychobiotics; Psychosis; Schizophrenia PMID: 32336581 DOI: 10.1016/j.schres.2020.02.010