The Effect of Exercise on Cancer-Related Cognitive Impairment and Applications for Physical Therapy: Systematic Review of Randomized Controlled Trials. Author: Campbell KL1, Zadravec K2, Bland KA3, Chesley E4, Wolf F5, Janelsins MC6 Affiliation: <sup>1</sup>Department of Physical Therapy, University of British Columbia 212-2177 Wesbrook Mall, Vancouver, British Columbia, Canada V7J 3K6. <sup>2</sup>Rehabilitation Sciences, University of British Colombia. <sup>3</sup>Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia. <sup>4</sup>Biology, University of British Columbia. <sup>5</sup>Institute for Cardiovascular Research and Sports Medicine, German Sport University, Cologne, Germany. <sup>6</sup>Surgery, University of Rochester, Rochester, New York. Conference/Journal: Phys Ther. Date published: 2020 Feb 17 Other: Pages: pzz090 , Special Notes: doi: 10.1093/ptj/pzz090. [Epub ahead of print] , Word Count: 279 BACKGROUND: Cancer-related cognitive impairment (CRCI), often called "chemo-brain" or "chemo-fog," is a common side effect among adults with cancer, which can persist well after treatment completion. Accumulating evidence demonstrates exercise can improve cognitive function in healthy older adults and adults with cognitive impairments, suggesting exercise may play a role in managing CRCI. PURPOSE: The purpose was to perform a systematic review of randomized controlled trials (RCTs) to understand the effect of exercise on CRCI. DATA SOURCES: Relevant literature was retrieved from CINAHL, Medline (Ovid), and EMBASE. STUDY SELECTION: Eligible articles were RCTs that prescribed aerobic, resistance, combined aerobic/resistance, or mind-body (eg, yoga or Qigong) exercise during or following cancer treatment and included cognitive function outcome measures. DATA EXTRACTION: Descriptive information and Cohen d effect sizes were directly extracted or calculated for included trials. DATA SYNTHESIS: Twenty-nine trials were included in the final analysis. A statistically significant effect of exercise on self-reported cognitive function, both during and postadjuvant treatment, was reported in 12 trials (41%) (Cohen d range: 0.24-1.14), most commonly using the EORTC QLQ-C30. Ten trials (34%) performed neuropsychological testing to evaluate cognitive function; however, only 3 trials in women with breast cancer reported a significant effect of exercise (Cohen d range: 0.41-1.47). LIMITATIONS: Few RCTs to date have evaluated the effect of exercise on CRCI as a primary outcome. Twenty-six trials (90%) in this review evaluated CRCI as secondary analyses. CONCLUSIONS: Evidence supporting exercise as a strategy to address CRCI is limited. Future research evaluating CRCI as a primary outcome, including self-reported and objective measures, is needed to confirm the possible role of exercise in preventing and managing cognitive impairments in adults with cancer. © 2020 American Physical Therapy Association. PMID: 32065236 DOI: 10.1093/ptj/pzz090