The Bioelectric Circuitry of the Cell.


Author: Tuszynski JA4,5,6 in Makarov S1, Horner M2, Noetscher G3

Affiliation: <sup>1</sup>Massachusetts General Hospital, Boston, MA, USA

<sup>2</sup>ANSYS, Inc., Evanston, IL, USA

<sup>3</sup>Worcester Polytechnic Institute, Worcester, MA, USA

<sup>4</sup>Department of Oncology, University of Alberta, Edmonton, AB, Canada

<sup>5</sup>Department of Physics, University of Alberta, Edmonton, AB, Canada

<sup>6</sup>DIMEAS, Politecnico di Torino, Turin, Italy
Conference/Journal: SourceBrain and Human Body Modeling: Computational Human Modeling at EMBC 2018 [Internet]. Cham (CH): Springer;
Date published: 2019 Aug 28
Other:
  Word Count: 122  
    Excerpt

This chapter presents an overview of electric conduction in living cells when viewed as a composition of bioelectric circuits. We review the cell’s components that are known to exhibit electric conduction properties and represent them as parts of a complex circuitry. In particular, we discuss conductivity of the membrane, ion channels, actin filaments, DNA, and microtubules, each of which play important roles in the biological functioning of the cell. A new picture emerges where electrical conduction within the cell is taking place in an integrated fashion and may explain synchronization and orchestration of the cell dynamics.



Copyright 2019, The Author(s).



Sections

11.1. Introduction

11.2. Ion Channel Conduction Effects

11.3. Actin Filament Conductivity

11.4. Microtubule Conductivity

11.5. Conclusions

Acknowledgments

References

PMID: 31725231

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